School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA; College of Pharmacy, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, South Korea.
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
J Control Release. 2023 Sep;361:766-776. doi: 10.1016/j.jconrel.2023.08.030. Epub 2023 Aug 22.
Topical treatments to modulate hair growth are generally limited by low drug bioavailability due to poor skin permeability. Here, we studied the use of STAR particles, which are millimeter-sized ceramic particles with protruding microneedles, to form micropores in the skin to increase skin permeability to hair growth-modulating drugs. STAR particle design and fabrication were optimized, and the resulting STAR particles were shown to reduce lag time and increase skin permeability to minoxidil and acyclovir by more than three-fold compared to no treatment in pig skin ex vivo. In rats, STAR particles also improved topical delivery of minoxidil and acyclovir, which resulted in an increase or a decrease in the number, length and/or thickness of hairs and/or the number of anagen-phase hair follicles after minoxidil or acyclovir treatment, respectively. Clinical exam and histological evaluation showed no evidence of skin irritation or other adverse effects of the treatments. We conclude that STAR particles can increase topical delivery of minoxidil and acyclovir to improve modulation of hair growth promotion and inhibition, respectively.
局部治疗药物来调节毛发生长通常受到限制，因为皮肤渗透率低导致药物生物利用度低。在这里，我们研究了使用 STAR 粒子（一种具有突出微针的毫米大小的陶瓷粒子）在皮肤上形成微孔，以增加毛发生长调节药物的皮肤渗透率。优化了 STAR 粒子的设计和制造，结果表明，与未经处理的猪皮相比，STAR 粒子将米诺地尔和阿昔洛韦的滞后时间减少了三分之二以上，并将其皮肤渗透率提高了三倍以上。在大鼠中，STAR 粒子还改善了米诺地尔和阿昔洛韦的局部递送，分别导致米诺地尔或阿昔洛韦治疗后毛发数量、长度和/或厚度和/或处于生长期的毛囊数量增加或减少。临床检查和组织学评估未显示治疗有皮肤刺激或其他不良反应的证据。我们得出结论，STAR 粒子可以增加米诺地尔和阿昔洛韦的局部递送，以分别改善毛发生长的促进和抑制调节。
