Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Rio de Janeiro, RJ, Brazil; Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Rio de Janeiro, Brazil.
Laboratory of Molecular Modeling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Rio de Janeiro, Brazil.
Chem Biol Interact. 2023 Sep 25;383:110678. doi: 10.1016/j.cbi.2023.110678. Epub 2023 Aug 16.
Nerve agents (NA) pose as a great risk in the modern world. NA from the V-series, such as VX, are currently recognized as the most toxic among those compounds. However, the emergence of new classes of toxicants recently included in the Chemical Weapons Convention (CWC), such as the A-series NA, a class of organophosphorus compounds related to phosphoramidates, pose a new source of concern due to the lack of information. In order advance in the investigation on the toxicity of such toxic chemicals, we performed in vitro studies to compare representatives of the V- and A-series using affordable surrogates. Results suggest a similar inhibition potency between both agents.
神经毒剂（NA）在现代世界构成了巨大的威胁。V 系列的 NA，如 VX，目前被认为是此类化合物中毒性最强的。然而，最近被列入《化学武器公约》（CWC）的新型毒剂类别的出现，如 A 系列 NA，一类与磷酰胺有关的有机磷化合物，由于缺乏信息，引起了人们新的关注。为了深入研究此类有毒化学物质的毒性，我们使用价格合理的替代物进行了体外研究，比较了 V 系列和 A 系列的代表物。结果表明，两种试剂具有相似的抑制效力。
