由柔红霉素产生微生物的阻断突变体产生的强效蒽环类抗生素奥沙诺霉素。
Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism.
作者信息
Yoshimoto A, Fujii S, Johdo O, Kubo K, Ishikura T, Naganawa H, Sawa T, Takeuchi T, Umezawa H
出版信息
J Antibiot (Tokyo). 1986 Jul;39(7):902-9. doi: 10.7164/antibiotics.39.902.
PMID:3759649
Abstract
A new potent anthracycline antibiotic oxaunomycin was isolated from the culture broth of a blocked mutant derived from a baumycin producer and was identified as 7-O-(alpha-L-daunosaminyl)-beta-rhodomycinone. It exhibited about 100 times more strongly cytotoxic activity against leukemic L1210 cell culture than doxorubicin.
摘要
一种新的强效蒽环类抗生素氧柔红霉素，是从一种由博来霉素产生菌衍生的阻断突变体的培养液中分离得到的，经鉴定为7-O-(α-L-柔红糖胺基)-β-红霉酮。它对白血病L1210细胞培养物的细胞毒性活性比阿霉素强约100倍。
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