• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

由柔红霉素产生微生物的阻断突变体产生的强效蒽环类抗生素奥沙诺霉素。

Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism.

作者信息

Yoshimoto A, Fujii S, Johdo O, Kubo K, Ishikura T, Naganawa H, Sawa T, Takeuchi T, Umezawa H

出版信息

J Antibiot (Tokyo). 1986 Jul;39(7):902-9. doi: 10.7164/antibiotics.39.902.

DOI:10.7164/antibiotics.39.902
PMID:3759649
Abstract

A new potent anthracycline antibiotic oxaunomycin was isolated from the culture broth of a blocked mutant derived from a baumycin producer and was identified as 7-O-(alpha-L-daunosaminyl)-beta-rhodomycinone. It exhibited about 100 times more strongly cytotoxic activity against leukemic L1210 cell culture than doxorubicin.

摘要

一种新的强效蒽环类抗生素氧柔红霉素，是从一种由博来霉素产生菌衍生的阻断突变体的培养液中分离得到的，经鉴定为7-O-(α-L-柔红糖胺基)-β-红霉酮。它对白血病L1210细胞培养物的细胞毒性活性比阿霉素强约100倍。

相似文献

1
Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism.由柔红霉素产生微生物的阻断突变体产生的强效蒽环类抗生素奥沙诺霉素。
J Antibiot (Tokyo). 1986 Jul;39(7):902-9. doi: 10.7164/antibiotics.39.902.
2
New anthracycline glycosides: 4-O-demethyl-11-deoxydoxorubicin and analogues from Streptomyces peucetius var. aureus.新型蒽环类糖苷：来自佩西链霉菌金黄色变种的4-O-去甲基-11-脱氧阿霉素及其类似物。
J Antibiot (Tokyo). 1982 Feb;35(2):176-83. doi: 10.7164/antibiotics.35.176.
3
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. I. Isolation of antibiotic-blocked mutants and their characterization.
J Antibiot (Tokyo). 1992 Aug;45(8):1255-67. doi: 10.7164/antibiotics.45.1255.
4
Production of new anthracycline antibiotics 1-hydroxy-oxaunomycin and 6-deoxyoxaunomycin by limited biosynthetic conversion using a daunorubicin-negative mutant.
J Antibiot (Tokyo). 1992 Oct;45(10):1609-17. doi: 10.7164/antibiotics.45.1609.
5
Isolation of new anthracyclines 10-O-rhodosaminyl beta-rhodomycinone and beta-isorhodomycinone from mild-acid treated culture of obelmycin-producing Streptomyces violaceus.从经温和酸处理的产奥贝霉素的紫色链霉菌培养物中分离新蒽环类化合物10-O-鼠李糖胺基β-玫瑰霉素酮和β-异玫瑰霉素酮。
J Antibiot (Tokyo). 1997 Jun;50(6):522-5. doi: 10.7164/antibiotics.50.522.
6
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5.
J Antibiot (Tokyo). 1993 Jan;46(1):56-64. doi: 10.7164/antibiotics.46.56.
7
Anthracycline metabolites from Streptomyces violaceus A262. II. New anthracycline epelmycins produced by a blocked mutant strain SU2-730.来自紫色链霉菌A262的蒽环类代谢产物。II. 由阻断突变株SU2-730产生的新型蒽环类埃佩霉素
J Antibiot (Tokyo). 1991 Oct;44(10):1121-9. doi: 10.7164/antibiotics.44.1121.
8
Microbial conversion of epsilon-pyrromycinone and epsilon-isorhodomycinone to 1-hydroxy-13-dihydrodaunomcyin and N-formyl-1-hydroxy-13-dihydrodaunomycin and their bioactivities.ε-吡咯霉素酮和ε-异玫瑰霉素酮向1-羟基-13-二氢柔红霉素和N-甲酰基-1-羟基-13-二氢柔红霉素的微生物转化及其生物活性。
J Antibiot (Tokyo). 1980 Oct;33(10):1150-7. doi: 10.7164/antibiotics.33.1150.
9
New anthracycline antibiotics, auramycins and sulfurmycins. I. Isolation and characterization of auramycins A and B, and sulfurmycins A and B.新型蒽环类抗生素、金霉素和硫霉素。I. 金霉素A和B以及硫霉素A和B的分离与特性鉴定。
J Antibiot (Tokyo). 1982 Feb;35(2):164-75. doi: 10.7164/antibiotics.35.164.
10
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. III. New anthracycline metabolites produced by blocked mutants 4L-660 and YDK-18.
J Antibiot (Tokyo). 1993 Nov;46(11):1758-61. doi: 10.7164/antibiotics.46.1758.

引用本文的文献

1
Streptomycetes producing daunomycin and related compounds: do we know enough about them after 25 years?产生柔红霉素及相关化合物的链霉菌：25年后我们对它们了解得够多了吗？
Folia Microbiol (Praha). 1989;34(4):324-49. doi: 10.1007/BF02814475.