Young Angela L, Kundu Suprateek, Tappa Karthik K, Hou Ping, Liu Ho-Ling, Kumar Vinodh A
Neuroradiology, The University of Texas MD Anderson Cancer Center, USA.
Biostatistics, The University of Texas MD Anderson Cancer Center, USA.
Neuroradiol J. 2023 Aug 18:19714009231196471. doi: 10.1177/19714009231196471.
Secondary language areas, including the pre-supplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), and the visual word form area (VWFA) play important roles in speech, but have been under-evaluated in the realm of resting-state (rs)-fMRI. The purpose of this study is to determine the incidence that secondary language areas and contralateral language areas can be localized using seed-based correlation (SBC) rs-fMRI.
We retrospectively reviewed 40 rs-fMRIs for functional connectivity (FC) to secondary language areas in cases where FC to Broca's or Wernicke's area near tumor in the left hemisphere were successfully generated using SBC analysis. Logistical regression was used for statistical analysis.
SBC rs-fMRI with a seed in the left Broca's or Wernicke's area ipsilateral to the tumor was performed in the 40 patients. 72.5% of cases showed FC to the left DLPFC, 67.5% to left pre-SMA, and 52.5% of cases had FC to right Broca's area. In addition to other correlations, we found older patients have a lower incidence of FC to the right Wernicke's area when seeded from both left Broca's and left Wernicke's area (-value = .016, odds ratio = 0.94).
SBC rs-fMRI can detect left hemispheric secondary language areas as well as right hemispheric primary and secondary language areas. The left DLPFC showed the highest incidence of FC, followed by the left pre-SMA when seeded from both left Broca's and Wernicke's area. Logistics regression also showed in some instances, differences in the incidence of FC to language areas was dependent on age, seed location, and gender.
包括前辅助运动区（pre-SMA）、背外侧前额叶皮层（DLPFC）和视觉词形区（VWFA）在内的二级语言区域在言语中发挥着重要作用，但在静息态功能磁共振成像（rs-fMRI）领域尚未得到充分评估。本研究的目的是确定使用基于种子点的相关性（SBC）rs-fMRI定位二级语言区域和对侧语言区域的发生率。
我们回顾性分析了40例rs-fMRI数据，这些数据用于分析与二级语言区域的功能连接（FC），分析对象为通过SBC分析成功生成左半球肿瘤附近布洛卡区或韦尼克区FC的病例。采用逻辑回归进行统计分析。
对40例患者进行了以肿瘤同侧左侧布洛卡区或韦尼克区为种子点的SBC rs-fMRI检查。72.5%的病例显示与左侧DLPFC有FC，67.5%与左侧pre-SMA有FC，52.5%的病例与右侧布洛卡区有FC。除其他相关性外，我们发现，当以左侧布洛卡区和左侧韦尼克区为种子点时，老年患者与右侧韦尼克区有FC的发生率较低（P值 = 0.016，比值比 = 0.94）。
SBC rs-fMRI可以检测到左半球的二级语言区域以及右半球的一级和二级语言区域。当以左侧布洛卡区和韦尼克区为种子点时，左侧DLPFC显示出最高的FC发生率，其次是左侧pre-SMA。逻辑回归还显示，在某些情况下，与语言区域有FC的发生率差异取决于年龄、种子点位置和性别。
