Nephrology Department, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
Nephrology Department, "Dr. Carol Davila" Teaching Hospital of Nephrology, Bucharest, Romania.
Ther Apher Dial. 2024 Feb;28(1):34-41. doi: 10.1111/1744-9987.14057. Epub 2023 Aug 19.
This retrospective study examined the relationship between the Glasgow Prognostic Score (GPS) at hemodialysis (HD) initiation and overall/cardiovascular mortality.
A total of 264 patients starting HD between 2014 and 2015 at a single center were studied. Follow-up persisted until therapy change, death, or study end (December 31, 2021), with a median of 6.8 years.
Patients with a higher GPS more frequently had emergent HD initiation and showed increased eGFR at initiation. During follow-up, 60% of patients died, with cardiovascular disease being the leading cause. Univariate analysis revealed a significant difference in median survival time across GPS classes. Cox proportional hazard models confirmed a significant association between GPS and mortality.
We report a significant association between GPS at HD initiation and mortality. GPS may prove useful as a prognostic tool for identifying high-risk patients, underscoring the need for future research to validate these findings and explore the potential of GPS-based interventions.
本回顾性研究探讨了血液透析（HD）起始时格拉斯哥预后评分（GPS）与全因/心血管死亡率之间的关系。
研究纳入了 2014 年至 2015 年期间在单中心开始 HD 的 264 名患者。随访持续至治疗改变、死亡或研究结束（2021 年 12 月 31 日），中位随访时间为 6.8 年。
GPS 较高的患者更频繁地接受紧急 HD 起始治疗，并在起始时显示出更高的 eGFR。随访期间，60%的患者死亡，心血管疾病是主要死因。单因素分析显示，GPS 类别之间的中位生存时间存在显著差异。Cox 比例风险模型证实 GPS 与死亡率之间存在显著关联。
我们报告了 HD 起始时 GPS 与死亡率之间的显著关联。GPS 可能作为识别高危患者的预后工具具有一定价值，这突显了未来研究验证这些发现并探讨基于 GPS 的干预措施的潜力的必要性。
