Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Jacksonville, Florida, U.S.A.
Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, U.S.A.
Laryngoscope. 2024 Feb;134(2):773-778. doi: 10.1002/lary.30964. Epub 2023 Aug 19.
The aim was to study laryngological complaints in patients with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD).
A total of 363 patients met inclusion for the study by completing questions related to voice, upper airway, and swallowing between July 7, 2020 and July 13, 2022. Demographic data, voice-related questions, and hypermobility diagnosis were analyzed retrospectively. From those, 289 patients were diagnosed with hEDS or HSD with 74 that did not meet the diagnostic criteria for either diagnosis serving as controls.
There were no statistically significant differences between patients with hEDS and HSD regarding Voice Handicap Index (VHI-10) scores, voice, upper airway, or swallow complaints. However, more hEDS/HSD patients answered positively to the laryngeal dysfunction question versus controls (p = 0.031). 22.5% of hEDS/HSD patients (n = 65) reported hoarseness, of which 52.3% reported hoarseness >2 days/month. 33.9% (n = 98) with hEDS/HSD reported symptoms of dysphagia, and 27.0% (n = 78) reported laryngeal dysfunction symptoms. Controls demonstrated 20.3% prevalence of hoarseness, of which 46.7% reported hoarseness >2 days/month. 24.3% of controls had dysphagia and 14.9% laryngeal dysfunction symptoms. Of the 363 patients, VHI-10 scores >11 were more likely in patients reporting >2 days of hoarseness/month (p = 0.001) versus those with <2 days of hoarseness/month. There was an increased prevalence of voice, upper airway, and dysphagia symptoms in hEDS/HSD patients compared with previously reported prevalence data in the general population.
A significant proportion of patients diagnosed with hypermobility due to hEDS or HSD were found to have voice, upper airway, and dysphagia symptoms. These rates are higher than those previously reported in the general population.
3 Laryngoscope, 134:773-778, 2024.
研究患有高弹性埃勒斯-当洛斯综合征（hEDS）或高弹性谱障碍（HSD）的患者的喉科投诉。
共有 363 名患者在 2020 年 7 月 7 日至 2022 年 7 月 13 日期间通过完成与声音、上呼吸道和吞咽相关的问题，符合研究条件。分析了人口统计学数据、与声音相关的问题和高弹性诊断情况。其中，289 名患者被诊断为 hEDS 或 HSD，74 名患者未符合这两种诊断中的任何一种诊断标准，作为对照组。
在 hEDS 和 HSD 患者的嗓音障碍指数（VHI-10）评分、声音、上呼吸道或吞咽投诉方面，没有统计学上的显著差异。然而，hEDS/HSD 患者中回答有喉功能障碍问题的比例高于对照组（p=0.031）。22.5%的 hEDS/HSD 患者（n=65）报告声音嘶哑，其中 52.3%的患者报告声音嘶哑>2 天/月。33.9%（n=98）的 hEDS/HSD 患者报告有吞咽困难症状，27.0%（n=78）报告有喉功能障碍症状。对照组显示声音嘶哑的患病率为 20.3%，其中 46.7%的患者报告声音嘶哑>2 天/月。对照组中有 24.3%的患者有吞咽困难，14.9%的患者有喉功能障碍症状。在 363 名患者中，VHI-10 评分>11 更可能发生在报告声音嘶哑>2 天/月的患者中（p=0.001），而报告声音嘶哑<2 天/月的患者则较少见。与之前报道的普通人群中发病率数据相比，hEDS/HSD 患者的声音、上呼吸道和吞咽困难症状的发病率更高。
由于 hEDS 或 HSD 而被诊断为高弹性的患者中，有相当比例的患者存在声音、上呼吸道和吞咽困难症状。这些比率高于之前在普通人群中报道的比率。
3 级喉镜检查，134：773-778，2024。
