Pichard Diane, Kurtz Maxime, Reyes-Gomez Edouard, Manassero Mathieu, Maurey Christelle
Internal Medicine Department, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.
Internal Medicine Department, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.
Top Companion Anim Med. 2023 Sep-Dec;56-57:100804. doi: 10.1016/j.tcam.2023.100804. Epub 2023 Aug 18.
A 3-month-old female French Bulldog presented with hematuria, severe pollakiuria, and urinary incontinence lasting for 1.5 months. Broad-spectrum empirical antibiotic therapy and nonsteroidal anti-inflammatory drugs were initiated by the referring veterinarian. Due to a lack of improvement, the dog was referred. At referral examination, urinary clinical signs persisted (hematuria, severe pollakiuria) and a firm bladder was noted. Abdominal ultrasonography revealed severe, diffuse bladder wall thickening with a significant reduction in the bladder lumen. Urinary tract endoscopy showed whitish exophytic proliferations throughout the entire bladder wall. Histological bladder wall analysis led to a diagnosis of bladder malakoplakia. Prolonged antibiotic therapy with fluoroquinolones was prescribed and resulted in clinical remission despite persistent bacteria in the bladder wall. This report describes a case of successfully medically managed bladder malakoplakia, a very rare condition in veterinary medicine, well documented in humans.
一只3个月大的法国斗牛犬母犬出现血尿、严重尿频和尿失禁，持续了1.5个月。转诊兽医开始了广谱经验性抗生素治疗和非甾体抗炎药治疗。由于病情没有改善，这只狗被转诊。在转诊检查时，泌尿临床症状仍然存在（血尿、严重尿频），并注意到膀胱坚硬。腹部超声检查显示膀胱壁严重弥漫性增厚，膀胱腔明显缩小。尿路内窥镜检查显示整个膀胱壁有白色外生性增生。膀胱壁组织学分析导致诊断为膀胱软斑病。尽管膀胱壁中仍有细菌存在，但使用氟喹诺酮类药物进行了长期抗生素治疗，临床症状得到缓解。本报告描述了一例成功通过药物治疗的膀胱软斑病病例，这在兽医学中是一种非常罕见的疾病，在人类中有详细记载。
