Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China; Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China.
Clin Chim Acta. 2023 Aug 1;548:117512. doi: 10.1016/j.cca.2023.117512. Epub 2023 Aug 19.
To explore association of serum hyaluronidase 1 (HYAL1) level in early pregnancy with gestational diabetes mellitus (GDM), and to examine interactive effects of HYAL1 with ceramides species on GDM risk.
We conducted a 1:1 matched case-control study (n = 414) of pregnant women from 2010 to 2012 in Tianjin, China. Blood samples were collected at the first antenatal care visit (at a median of 10 gestational weeks). Binary conditional logistic regression and restricted cubic spline (RCS) analysis were used to examine full-range risk association between HYAL1 and GDM. Additive interactions and multiplicative interactions were employed to test interactive effects of HYAL1 with ceramides species on GDM risk.
Ln HYAL1 was linearly associated with GDM risk and the adjusted OR of HYAL1 ≥ vs. < its median for GDM was significant (1.65, 95%CI: 1.08-2.52). High HYAL1 markedly enhanced the ORs of high ceramide 18:0 for GDM from 2.31 (1.06-5.01) to 6.74 (2.85-16.0), and low ceramide 24:0 from 3.08 (1.33-7.11) to 8.15 (3.03-21.9), with significant additive interactions.
High HYAL1 in early pregnancy may increase the risk of GDM in Chinese women, possibly via enhancing the effects of high ceramide 18:0 and low ceramide 24:0 on GDM risk.
探讨妊娠早期血清透明质酸酶 1（HYAL1）水平与妊娠期糖尿病（GDM）的关联，并研究 HYAL1 与神经酰胺种类之间的交互作用对 GDM 发病风险的影响。
我们进行了一项 2010 年至 2012 年期间在中国天津进行的 1:1 匹配病例对照研究（n=414），纳入了孕妇。在第一次产前检查时（中位数为妊娠 10 周时）采集血样。采用二元条件 logistic 回归和限制三次样条（RCS）分析来检验 HYAL1 与 GDM 之间的全范围风险关联。采用加性交互作用和乘法交互作用检验 HYAL1 与神经酰胺种类对 GDM 发病风险的交互作用。
Ln HYAL1 与 GDM 发病风险呈线性相关，且 HYAL1≥vs. <其中位数与 GDM 的调整后 OR 有统计学意义（1.65，95%CI：1.08-2.52）。高 HYAL1 使神经酰胺 18:0 水平高与 GDM 的 OR 从 2.31（1.06-5.01）显著增加至 6.74（2.85-16.0），神经酰胺 24:0 水平低与 GDM 的 OR 从 3.08（1.33-7.11）显著增加至 8.15（3.03-21.9），且具有统计学意义的加性交互作用。
妊娠早期高 HYAL1 可能会增加中国女性 GDM 的发病风险，其机制可能是增强了神经酰胺 18:0 水平高和神经酰胺 24:0 水平低对 GDM 发病风险的影响。
