Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Diabetes Res Clin Pract. 2021 Jan;171:108606. doi: 10.1016/j.diabres.2020.108606. Epub 2020 Dec 10.
To explore associations between ceramides in early pregnancy and gestational diabetes mellitus (GDM); and interactions between ceramides and trimethylamine N-oxide (TMAO) metabolites for GDM.
We organized a 1:1 nested case-control study (n = 486) from a prospective cohort of pregnant women. Conditional logistic regression and additive interaction were performed to examine relationships between ceramides and TMAO metabolites for GDM. We defined trimethylamine (TMA) conversion ratio (TMA) as TMA/its precursors and TMAO conversion ratio (TMAO) as TMAO/TMA. Copresence of high TMA and low TMAO indicated TMA accumulation status.
High ceramides 18:0 (per SD), 18:1 (per SD) and low ceramide 24:0 (≤ 3.60 nmol/mL) were associated with increased GDM risk (OR: 1.69, 1.72 & 3.59, respectively). High TMA enhanced the OR of low ceramide 24:0 for GDM from 1.53 (95%CI: 0.88-2.66) to 10.3 (2.83-37.5), high TMA enhanced it from 1.31 (0.67-2.56) to 24.3 (6.57-89.5) and TMA accumulation enhanced it from 1.42 (0.72-2.77) to 25.5 (6.80-95.7), with all additive interactions being significant. However, the interactions between high ceramide 18 and TMAO metabolites were not significant.
High ceramides 18:0, 18:1 and low ceramide 24:0 in early pregnancy were associated with increased GDM risk. Notably, TMA accumulation greatly amplified the risk-promoting effect of low ceramide 24:0 for GDM.
探讨妊娠早期神经酰胺与妊娠期糖尿病（GDM）的关系；并探讨神经酰胺与三甲胺 N-氧化物（TMAO）代谢物在 GDM 中的相互作用。
我们组织了一项前瞻性队列孕妇的 1:1 巢式病例对照研究（n=486）。采用条件逻辑回归和加性交互作用检验神经酰胺与 TMAO 代谢物与 GDM 的关系。我们将三甲胺（TMA）转化率（TMA）定义为 TMA/其前体和 TMAO 转化率（TMAO）定义为 TMAO/TMA。高 TMA 和低 TMAO 的共存表明 TMA 积累状态。
高神经酰胺 18:0（每 SD）、18:1（每 SD）和低神经酰胺 24:0（≤3.60 nmol/mL）与 GDM 风险增加相关（OR：1.69、1.72 和 3.59）。高 TMA 使低神经酰胺 24:0 与 GDM 的 OR 从 1.53（95%CI：0.88-2.66）增加到 10.3（2.83-37.5），从 1.31（0.67-2.56）增加到 24.3（6.57-89.5），TMA 积累使 OR 从 1.42（0.72-2.77）增加到 25.5（6.80-95.7），所有加性交互作用均有统计学意义。然而，高神经酰胺 18 与 TMAO 代谢物之间的相互作用不显著。
妊娠早期高神经酰胺 18:0、18:1 和低神经酰胺 24:0 与 GDM 风险增加有关。值得注意的是，TMA 积累大大放大了低神经酰胺 24:0 对 GDM 的促发作用。
