Ishida Akihiro, Ohta Midori, Kobayashi Takafumi, Yamamoto Yoshinori, Hori Ayaka, Ryu Masahiro, Ueda Takayuki
Department of Removable Prosthodontics and Gerodontology, Tokyo Dental College.
Bull Tokyo Dent Coll. 2023 Dec 28;64(3):97-104. doi: 10.2209/tdcpublication.2022-0039. Epub 2023 Aug 18.
The aim of this randomized crossover trial was to clarify the effects of chewing gummy jelly containing a compound of decanoic acid, oligonol, methyl cellulose, and citral (DOMAC) on mental stress and autonomic nervous activity in facemask wearers. A placebo gummy jelly was used in conjunction with DOMAC. Eight healthy adults with no tooth loss (mean age: 35±5 yr) were included. The participants were required to chew one DOMAC or placebo gummy jelly for 5 min after wearing a facemask for 20 min in the laboratory, then the other gummy jelly after a washout period. Rate of change in salivary immunoglobulin A (IgA) as a marker of stress was compared between before and after chewing. Additionally, sympathetic and parasympathetic activity was compared at both time points. A significant difference was observed in the percentage change in salivary IgA from that at before wearing a facemask: 127±34% (mean±standard deviation) while wearing a facemask; 46±20% while chewing DOMAC gummies; and 47±26% while chewing placebo gummies (p<0.05). Parasympathetic nervous system activity was 971.2±1040.7 ms at 20 min after facemask wearing; 295.0±253.0 ms after DOMAC gummy chewing; and 1956.1±2798.0 ms after chewing a placebo gummy jelly; with significant differences only being found between 20 min after facemask wearing and after DOMAC gummy chewing (p<0.05). Sympathetic nervous system activity was 1.80±1.83 at 20 min after facemask wearing; 4.06±3.33 after DOMAC gummy chewing; and 4.95±7.02 after chewing a placebo gummy jelly; with significant differences only being found between 20 min after facemask wearing and after DOMAC gummy chewing. These results suggest that chewing gummy jellies containing DOMAC relieves stress caused by facemask wearing and activates sympathetic nervous system activity.
这项随机交叉试验的目的是阐明咀嚼含有癸酸、低聚酚、甲基纤维素和柠檬醛（DOMAC）化合物的软糖对戴口罩者心理压力和自主神经活动的影响。使用了一种安慰剂软糖与DOMAC软糖配合使用。纳入了8名无牙齿缺失的健康成年人（平均年龄：35±5岁）。参与者被要求在实验室戴口罩20分钟后咀嚼一颗DOMAC或安慰剂软糖5分钟，然后在洗脱期后咀嚼另一颗软糖。比较了咀嚼前后作为压力标志物的唾液免疫球蛋白A（IgA）的变化率。此外，在两个时间点比较了交感神经和副交感神经活动。观察到戴口罩前唾液IgA的百分比变化有显著差异：戴口罩时为127±34%（平均值±标准差）；咀嚼DOMAC软糖时为46±20%；咀嚼安慰剂软糖时为47±26%（p<0.05）。副交感神经系统活动在戴口罩后20分钟时为971.2±1040.7毫秒；咀嚼DOMAC软糖后为295.0±253.0毫秒；咀嚼安慰剂软糖后为1956.1±2798.0毫秒；仅在戴口罩后20分钟和咀嚼DOMAC软糖后之间发现显著差异（p<0.05）。交感神经系统活动在戴口罩后20分钟时为1.80±1.83；咀嚼DOMAC软糖后为4.06±3.33；咀嚼安慰剂软糖后为4.95±7.02；仅在戴口罩后20分钟和咀嚼DOMAC软糖后之间发现显著差异。这些结果表明，咀嚼含有DOMAC的软糖可缓解戴口罩引起的压力并激活交感神经系统活动。
