Kinetics and dynamics of single doses of oxazepam in the elderly: implications of absorption rate.

Five healthy elderly volunteers aged 64 to 67 years and 12 healthy young subjects aged 23 to 44 years received single 30 mg oral doses of oxazepam in two different dosage forms (two 15 mg tablets or one 30 mg capsule) on two occasions in a random crossover sequence, with at least 1 week elapsing between trials. In both age groups, rate of oxazepam absorption of the capsule form of the drug was significantly slower than that of the tablets. Peak plasma concentrations were lower and were delayed longer with the capsule form; however, the relative extent of oxazepam absorption did not differ between preparations in either age group. Clinical self-ratings in the elderly group, based on visual analog scales, were consistent with the delayed onset of sedative effects that is associated with the capsule form of administration. Kinetic comparisons in the two groups indicated a significantly prolonged oxazepam elimination half-life with the tablet (p less than .001) and with the capsule (p less than .06) and a trend (p less than .08) toward reduced oxazepam clearance in the elderly. The delayed absorption of oxazepam from the capsule was found in both the young and elderly groups.