Department of Microbiology, Peshawar Medical College, Peshawar, Pakistan.
Institute of Microbiology, Faculty of Veterinary Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Pak J Pharm Sci. 2023 Jul;36(4):1107-1112.
In the community and among hospitalized patients, urinary tract infections (UTIs) rank as the most common bacterial infections. The researchers processed urine samples obtained from affiliated hospitals of Peshawar Medical College. The samples were examined under a microscope to assess the presence of bacteria, pus cells and red blood cells. Following this, the samples were inoculated on MacConkey and blood agar and subsequent antibiotic susceptibility testing was conducted. The findings revealed that 35.9% of hospitalized patients and 16.9% of outpatients were diagnosed with UTIs. Furthermore, 82.2% of the identified UTIs were found to be multidrug-resistant (MDR), with MDR Escherichia coli accounting for 77% of cases. Trimethoprim sulfamethazine (26.8%), penicillin (0%), cefepime (27.8%), cefotaxime (23.7%), aztreonam (2.1%), meropenem (86.6%), ciprofloxacin (51.5%), amoxicillin/clavulanic acid (37.1%), nitrofurantoin (70.1%), gentamycin (73%), ceftazidime (19.5%), levofloxacin (51.5%) and ceftriaxone (25.77%) were subjected to antibiotic susceptibility testing. It is concerning that among the 13 antibiotics examined, solely nitrofurantoin displayed oral efficacy as an effective treatment choice for UTIs.
在社区和住院患者中，尿路感染 (UTI) 是最常见的细菌性感染。研究人员处理了来自白沙瓦医学院附属医院的尿液样本。这些样本在显微镜下检查，以评估是否存在细菌、脓细胞和红细胞。之后，这些样本被接种在麦康凯琼脂和血琼脂上，并进行了后续的抗生素敏感性测试。结果显示，35.9%的住院患者和 16.9%的门诊患者被诊断患有 UTI。此外，82.2%的确诊 UTI 为多药耐药 (MDR)，其中 MDR 大肠杆菌占 77%。甲氧苄啶磺胺甲恶唑 (26.8%)、青霉素 (0%)、头孢吡肟 (27.8%)、头孢噻肟 (23.7%)、氨曲南 (2.1%)、美罗培南 (86.6%)、环丙沙星 (51.5%)、阿莫西林/克拉维酸 (37.1%)、呋喃妥因 (70.1%)、庆大霉素 (73%)、头孢他啶 (19.5%)、左氧氟沙星 (51.5%)和头孢曲松 (25.77%)接受了抗生素敏感性测试。令人担忧的是，在所检查的 13 种抗生素中，仅有呋喃妥因显示出口服疗效，是治疗 UTI 的有效选择。
