College of Pharmacy, University of Sargodha, Sargodha, Pakistan/Colleage of Medicine, Medical University of South Carolina, Charleston, SC, USA.
College of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Pak J Pharm Sci. 2023 Jul;36(4):1227-1232.
Anagallis arvensis L. has several health benefits, such as it is an effective remedy for epileptic disorders, leprosy, rheumatism, and hepatic and renal dysfunctions. However, scientific evidence of the plant against liver disease is not reported so far. Thus, the aim of the present study was to highlight the hepatoprotective and hepatocurative effect of extract on hepatic injury induced by carbon tetrachloride (CCl). The extract was investigated for its effect on hematological parameters, liver enzymes regulation, and anti-oxidant markers (SOD & CAT). In addition, histopathological investigations were performed. This extract displayed significant reversion of WBCs, RBCs, platelets count, hemoglobin, ALT, AST, ALP and albumin levels towards the normal level as compared with control. Therefore, there was significant rise in level of SOD and CAT in both groups (hepatocurative and protective). Furthermore, histological investigation demonstrated the preventive effect. The presence of alkaloids, carbohydrates, protein, phenolic compounds, tannins and saponins in the extract was confirmed by the preliminary phytochemical studies. Thus, based on all these facts, it can be concluded that Anagallis arvensis extract has restorative capability against CCl-induced hepatotoxicity and could be used as the hepatocurative and hepatoprotective agent, which could be attributed to the reported secondary metabolites.
琉璃苣具有多种健康益处，例如，它是治疗癫痫、麻风病、风湿、肝肾功能障碍的有效药物。然而，目前尚未有关于该植物治疗肝病的科学证据。因此，本研究的目的是强调琉璃苣提取物对四氯化碳（CCl）诱导的肝损伤的保肝和肝修复作用。研究了该提取物对血液学参数、肝脏酶调节和抗氧化标记物（SOD 和 CAT）的影响。此外，还进行了组织病理学研究。与对照组相比，该提取物能显著恢复白细胞计数（WBCs）、红细胞计数（RBCs）、血小板计数、血红蛋白、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）和白蛋白水平，使其恢复至正常水平。因此，两组的 SOD 和 CAT 水平均显著升高（肝修复和肝保护）。此外，组织学研究表明，该提取物具有预防作用。初步的植物化学研究证实了提取物中存在生物碱、碳水化合物、蛋白质、酚类化合物、单宁和皂苷。因此，基于所有这些事实，可以得出结论，琉璃苣提取物具有修复 CCl 诱导的肝毒性的能力，可以用作肝修复和肝保护剂，这可以归因于报道的次生代谢物。
