Cirrincione Peter M, Thakur Ankush, Zucker Colson P, Wisch Jenna L, Groisser Benjamin N, Nguyen Joseph, Mintz Douglas N, Cunningham Matthew E, Hresko M Timothy, Haddas Ram, Hillstrom Howard J, Widmann Roger F, Heyer Jessica H
Hospital for Special Surgery, New York, NY.
Boston Children's Hospital, Boston, MA.
J Pediatr Orthop. 2023;43(10):608-614. doi: 10.1097/BPO.0000000000002493. Epub 2023 Aug 21.
Up to 75% of patients with idiopathic scoliosis (IS) report back pain, but the exact contributors are unclear. This study seeks to assess how pain correlates with demographics, radiographic and surface topographic (ST) measurements, and patient-reported outcome measures (PROMs) in patients with IS.
Patient-Reported Outcome Measurement Information System (PROMIS) Pain Interference (PI) and Scoliosis Research Society revised (SRS-22r) pain domain from an IRB approved prospectively collected registry containing patients 11 to 21 years old with IS were correlated (Spearman coefficients) with measurements from whole-body EOS radiography and ST scanning, PROMIS 1.0 PROMs, Trunk Appearance Perception Scale (TAPS), and SRS-22r domains. SRS-22r and PROMIS-PI were also compared between different sex, scoliosis severities, and primary curve locations with Mann-Whitney U or Kruskal-Wallis tests, and if significant differences were found, included with the 5 highest univariate correlated variables into stepwise multivariate linear regression models ( P <0.05 to enter, P >0.1 to remove) predicting SRS-22r pain and PROMIS-PI.
One hundred and forty-nine patients (14.5 ± 2.0 y, body mass index 20.6 ± 4.1 kg/m 2 , 96 (64%) female, mean major coronal curve 40 ± 19 deg, range: 10 deg, 83 deg) reported mean PROMIS-PI of 42.2 ± 10.0 and SRS-22r pain of 4.4 ± 0.6. SRS-22r self-image was the most correlated variable with both SRS-22r pain (rho=0.519) and PROMIS-PI (rho=-0.594). Five variables, none of which were ST or radiographic measures, strongly predicted SRS pain domain (R=0.711, R2=0.505, N=138). Two variables (SRS-22r self-image and SRS-22r function) were utilized by a model correlated with PROMIS-PI (R=0.687, R2=0.463, N=124).
SRS-22r function and self-image domains were more strongly correlated with SRS-22r pain and PROMIS-PI than any radiographic or ST measurements.
Level II-retrospective study.
高达75%的特发性脊柱侧凸（IS）患者报告有背痛，但确切的影响因素尚不清楚。本研究旨在评估疼痛与IS患者的人口统计学、影像学和表面地形学（ST）测量以及患者报告结局指标（PROMs）之间的相关性。
将患者报告结局测量信息系统（PROMIS）疼痛干扰（PI）和脊柱侧凸研究学会修订版（SRS-22r）疼痛领域与来自全身EOS影像学和ST扫描、PROMIS 1.0 PROMs、躯干外观感知量表（TAPS）以及SRS-22r领域的测量值进行相关性分析（Spearman系数），这些数据来自一个经机构审查委员会批准的前瞻性收集的登记册，其中包含11至21岁的IS患者。还使用Mann-Whitney U检验或Kruskal-Wallis检验比较不同性别、脊柱侧凸严重程度和主要弯曲部位之间的SRS-22r和PROMIS-PI，如果发现显著差异，则将5个最高的单变量相关变量纳入逐步多元线性回归模型（P<0.05纳入，P>0.1剔除），以预测SRS-22r疼痛和PROMIS-PI。
149例患者（年龄14.5±2.0岁，体重指数20.6±4.1kg/m²，96例（64%）为女性，平均主冠状面弯曲40±19度，范围：10度至83度）报告的平均PROMIS-PI为42.2±10.0，SRS-22r疼痛为4.4±0.6。SRS-22r自我形象是与SRS-22r疼痛（rho=0.519）和PROMIS-PI（rho=-0.594）相关性最高的变量。五个变量（均不是ST或影像学测量指标）能强烈预测SRS疼痛领域（R=0.711，R²=0.505，N=138）。一个与PROMIS-PI相关的模型使用了两个变量（SRS-22r自我形象和SRS-22r功能）（R=0.687，R²=0.463，N=124）。
SRS-22r功能和自我形象领域与SRS-22r疼痛和PROMIS-PI的相关性比任何影像学或ST测量更强。
II级——回顾性研究。
