Li Zhonglin, Wu Xiaoling, Gao Hui, Xiang Tianyuan, Zhou Jing, Zou Zhi, Tong Li, Yan Bin, Zhang Chi, Wang Linyuan, Wang Wen, Yang Tingting, Li Fengyun, Ma Huimin, Zhao Xiaojuan, Mi Na, Yu Ziya, Li Hao, Zeng Qiang, Li Yongli
Department of Radiology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.
Department of Nuclear Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.
Front Neurosci. 2023 Aug 3;17:1201169. doi: 10.3389/fnins.2023.1201169. eCollection 2023.
Intermittent energy restriction (IER) is an effective weight loss strategy. However, the accompanying changes in spontaneous neural activity are unclear, and the relationship among anthropometric measurements, biochemical indicators, and adipokines remains ambiguous.
Thirty-five obese adults were recruited and received a 2-month IER intervention. Data were collected from anthropometric measurements, blood samples, and resting-state functional magnetic resonance imaging at four time points. The regional homogeneity (ReHo) method was used to explore the effects of the IER intervention. The relationships between the ReHo values of altered brain regions and changes in anthropometric measurements, biochemical indicators, and adipokines (leptin and adiponectin) were analyzed.
Results showed that IER significantly improved anthropometric measurements, biochemical indicators, and adipokine levels in the successful weight loss group. The IER intervention for weight loss was associated with a significant increase in ReHo in the bilateral lingual gyrus, left calcarine, and left postcentral gyrus and a significant decrease in the right middle temporal gyrus and right cerebellum (VIII). Follow-up analyses showed that the increase in ReHo values in the right LG had a significant positive correlation with a reduction in Three-factor Eating Questionnaire (TFEQ)-disinhibition and a significant negative correlation with an increase in TFEQ-cognitive control. Furthermore, the increase in ReHo values in the left calcarine had a significant positive correlation with the reduction in TFEQ-disinhibition. However, no significant difference in ReHo was observed in the failed weight loss group.
Our study provides objective evidence that the IER intervention reshaped the ReHo of some brain regions in obese individuals, accompanied with improved anthropometric measurements, biochemical indicators, and adipokines. These results illustrated that the IER intervention for weight loss may act by decreasing the motivational drive to eat, reducing reward responses to food cues, and repairing damaged food-related self-control processes. These findings enhance our understanding of the neurobiological basis of IER for weight loss in obesity.
间歇性能量限制（IER）是一种有效的减肥策略。然而，伴随而来的自发神经活动变化尚不清楚，人体测量指标、生化指标和脂肪因子之间的关系也仍不明确。
招募了35名肥胖成年人，并对他们进行了为期2个月的IER干预。在四个时间点收集了人体测量数据、血液样本和静息态功能磁共振成像数据。采用局部一致性（ReHo）方法来探究IER干预的效果。分析了大脑区域ReHo值变化与人体测量指标、生化指标和脂肪因子（瘦素和脂联素）变化之间的关系。
结果显示，在成功减肥组中，IER显著改善了人体测量指标、生化指标和脂肪因子水平。减肥的IER干预与双侧舌回、左侧距状裂和左侧中央后回的ReHo显著增加以及右侧颞中回和右侧小脑（VIII）的ReHo显著降低有关。后续分析表明，右侧舌回ReHo值的增加与三因素饮食问卷（TFEQ）-去抑制的降低呈显著正相关，与TFEQ-认知控制的增加呈显著负相关。此外，左侧距状裂ReHo值的增加与TFEQ-去抑制的降低呈显著正相关。然而，在减肥失败组中未观察到ReHo有显著差异。
我们的研究提供了客观证据，表明IER干预重塑了肥胖个体某些脑区的ReHo，同时改善了人体测量指标、生化指标和脂肪因子。这些结果表明，减肥的IER干预可能通过降低进食的动机驱动力、减少对食物线索的奖赏反应以及修复受损的食物相关自我控制过程来发挥作用。这些发现增强了我们对肥胖中IER减肥神经生物学基础的理解。
