Kakaei Nasrin, Amirian Roshanak, Azadi Mehdi, Mohammadi Ghobad, Izadi Zhila
Student Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Front Bioeng Biotechnol. 2023 Aug 3;11:1115254. doi: 10.3389/fbioe.2023.1115254. eCollection 2023.
Perfluorocarbon (PFC) are biocompatible compounds, chemically and biologically inert, and lacks toxicity as oxygen carriers. PFCs nanoemulsions and nanoparticles (NPs) are highly used in diagnostic imaging and enable novel imaging technology in clinical imaging modalities to notice and image pathological and physiological alterations. Therapeutics with PFCs such as the innovative approach to preventing thrombus formation, PFC nanodroplets utilized in ultrasonic medication delivery in arthritis, or PFC-based NPs such as Perfluortributylamine (PFTBA), Pentafluorophenyl (PFP), Perfluorohexan (PFH), Perfluorooctyl bromide (PFOB), and others, recently become renowned for oxygenating tumors and enhancing the effects of anticancer treatments as oxygen carriers for tumor hypoxia. In this review, we will discuss the recent advancements that have been made in PFC's applications in theranostic (therapeutics and diagnostics) as well as assess the benefits and drawbacks of these applications.
全氟化碳（PFC）是生物相容性化合物，在化学和生物学上呈惰性，作为氧载体没有毒性。PFC纳米乳液和纳米颗粒（NP）在诊断成像中被大量使用，并在临床成像模式中实现了新型成像技术，以检测和成像病理和生理变化。含有PFC的疗法，如预防血栓形成的创新方法、用于关节炎超声药物递送的PFC纳米液滴，或基于PFC的NP，如全氟三丁胺（PFTBA）、五氟苯基（PFP）、全氟己烷（PFH）、全氟辛基溴（PFOB）等，最近作为肿瘤缺氧的氧载体，在给肿瘤供氧和增强抗癌治疗效果方面声名远扬。在本综述中，我们将讨论PFC在治疗诊断（治疗和诊断）应用方面的最新进展，并评估这些应用的优缺点。
