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Perfluorocarbons: A perspective of theranostic applications and challenges.

作者信息

Kakaei Nasrin, Amirian Roshanak, Azadi Mehdi, Mohammadi Ghobad, Izadi Zhila

机构信息

Student Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Front Bioeng Biotechnol. 2023 Aug 3;11:1115254. doi: 10.3389/fbioe.2023.1115254. eCollection 2023.

DOI:10.3389/fbioe.2023.1115254
PMID:37600314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10436007/
Abstract

Perfluorocarbon (PFC) are biocompatible compounds, chemically and biologically inert, and lacks toxicity as oxygen carriers. PFCs nanoemulsions and nanoparticles (NPs) are highly used in diagnostic imaging and enable novel imaging technology in clinical imaging modalities to notice and image pathological and physiological alterations. Therapeutics with PFCs such as the innovative approach to preventing thrombus formation, PFC nanodroplets utilized in ultrasonic medication delivery in arthritis, or PFC-based NPs such as Perfluortributylamine (PFTBA), Pentafluorophenyl (PFP), Perfluorohexan (PFH), Perfluorooctyl bromide (PFOB), and others, recently become renowned for oxygenating tumors and enhancing the effects of anticancer treatments as oxygen carriers for tumor hypoxia. In this review, we will discuss the recent advancements that have been made in PFC's applications in theranostic (therapeutics and diagnostics) as well as assess the benefits and drawbacks of these applications.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/c6ded24e4551/fbioe-11-1115254-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/0d08d03fa5e7/fbioe-11-1115254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/26d6f4e87faa/fbioe-11-1115254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/25dbc68c07bc/fbioe-11-1115254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/9fe8fa7efe7d/fbioe-11-1115254-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/c6ded24e4551/fbioe-11-1115254-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/0d08d03fa5e7/fbioe-11-1115254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/26d6f4e87faa/fbioe-11-1115254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/25dbc68c07bc/fbioe-11-1115254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/9fe8fa7efe7d/fbioe-11-1115254-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/256c/10436007/c6ded24e4551/fbioe-11-1115254-g005.jpg

相似文献

[1]
Perfluorocarbons: A perspective of theranostic applications and challenges.

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[2]
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[10]
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引用本文的文献

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J Tissue Eng. 2025-6-29

[2]
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J Mater Chem B. 2025-5-23

[3]
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Front Chem. 2025-4-4

[4]
Oxygen-Releasing Nanodroplets Relieve Intratumoral Hypoxia and Potentiate Photodynamic Therapy in 3D Head and Neck Cancer Spheroids.

ACS Biomater Sci Eng. 2025-4-14

[5]
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[6]
Nanobubble Contrast Enhanced Ultrasound Imaging: A Review.

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[7]
Engineering Hyperechogenic Colloids with Clot-Targeting Capabilities from Platelet-Derived Membranes.

ACS Appl Mater Interfaces. 2024-10-3

[8]
Vaporization of perfluorocarbon attenuates sea-water-drowning-induced acute lung injury by deactivating the NLRP3 inflammasomes in canines.

Exp Biol Med (Maywood). 2024

本文引用的文献

[1]
Non-invasive mapping of systemic neutrophil dynamics upon cardiovascular injury.

Nat Cardiovasc Res. 2023-2

[2]
Cytosolic perfluorocarbon delivery to platelets via albumin for antithrombotic therapy.

J Control Release. 2023-3

[3]
Fluorine-Containing Covalent Organic Frameworks: Synthesis and Application.

Macromol Rapid Commun. 2023-6

[4]
Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments.

J Pharm Investig. 2023

[5]
An Osimertinib-Perfluorocarbon Nanoemulsion with Excellent Targeted Therapeutic Efficacy in Non-small Cell Lung Cancer: Achieving Intratracheal and Intravenous Administration.

ACS Nano. 2022-8-23

[6]
NIR-Mediated drug release and tumor theranostics using melanin-loaded liposomes.

Biomater Res. 2022-6-3

[7]
Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives.

Pharmaceuticals (Basel). 2022-4-1

[8]
A Scoping Review of Promising Alternative Blood Products for Prolonged Field Care.

Med J (Ft Sam Houst Tex). 2022

[9]
A new era in oxygen therapeutics? From perfluorocarbon systems to haemoglobin-based oxygen carriers.

Blood Rev. 2022-7

[10]
Photoacoustic nanodroplets for oxygen enhanced photodynamic therapy of cancer.

Photoacoustics. 2021-9-27

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