Van Nimmen D, Weyne J, Demeester G, Leusen I
J Cereb Blood Flow Metab. 1986 Oct;6(5):584-9. doi: 10.1038/jcbfm.1986.105.
The effect of ventriculocisternal perfusion with mock CSF with alkaline or acidic pH on the local CMRglu (LCMRglu) in the caudatoputamen was studied in artificially ventilated and relaxed rats. In control rats both lateral cerebral ventricles were perfused with mock CSF at pH 7.4. In the experimental series one cerebral ventricle was infused with normal mock CSF while the other was infused with mock CSF in which the pH was decreased or increased by changing [HCO-3]. LCMRglu was depressed in acidotic brain tissue while it was strongly increased in alkalotic brain tissue. The importance of these alterations in brain glucose metabolism for the homeostatic regulation of brain pH is discussed.
在人工通气且放松的大鼠中，研究了用pH呈碱性或酸性的模拟脑脊液进行脑室池灌注对尾状核壳核局部葡萄糖代谢率（LCMRglu）的影响。在对照大鼠中，两个侧脑室均用pH 7.4的模拟脑脊液灌注。在实验系列中，一个脑室注入正常模拟脑脊液，而另一个脑室注入通过改变[HCO₃⁻]使pH降低或升高的模拟脑脊液。酸中毒脑组织中的LCMRglu降低，而碱中毒脑组织中的LCMRglu则显著升高。讨论了脑葡萄糖代谢的这些改变对脑pH稳态调节的重要性。
