Li Xinghui, Ni Jiaqi, Chen Li
West China School of Pharmacy, Sichuan University, Chengdu, China.
Department of Pharmacy, Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.
Front Pharmacol. 2023 Aug 4;14:1239395. doi: 10.3389/fphar.2023.1239395. eCollection 2023.
Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AILI, this review focuses on novel findings in the field of diagnosis, screening, and management of AILI. It highlights the current issues that need to be addressed. This review is supposed to summarize the recent research progress and make recommendations for future research.
对乙酰氨基酚（APAP）过量是药物性肝损伤和急性肝衰竭的重要原因。由于涉及的机制复杂，APAP诱导的肝损伤（AILI）的诊断、筛查和管理具有挑战性。从目前关于AILI机制的研究出发，本综述重点关注AILI诊断、筛查和管理领域的新发现。它突出了当前需要解决的问题。本综述旨在总结近期的研究进展并为未来研究提出建议。
