Ahmed Naguy, Child/Adolescent Psychiatrist, Al-Manara CAP Centre, Kuwait Centre for Mental Health (KCMH), Jamal Abdul-Nassir St, Shuwaikh, State of Kuwait.
Camellia Naguy, Private Psychiatric Practice, Alexandria, Egypt.
Psychopharmacol Bull. 2023 Aug 11;53(3):69-72.
Pseudotumor cerebri or idiopathic intracranial hypertension (IIH) secondary to psychotropic drugs is a very rare occurrence. Lithium is typically the culprit agent. Here, authors report on an interesting case of an adolescent with early-onset schizophrenia that develops a reversible IIH putatively related to olanzapine-induced weight gain. This is followed by discussion of purported pharmacodynamic mechanisms and brief review of literature. Clinicians should be cognizant to this serious complication given the propensity of the majority of atypical antipsychotics to induce significant weight gain especially in younger population.
由精神药物引起的假性脑瘤或特发性颅内高压（IIH）非常罕见。通常，锂是罪魁祸首。在这里，作者报告了一个有趣的病例，一名青少年精神分裂症患者由于奥氮平引起的体重增加而出现可逆转的 IIH。随后讨论了推测的药效学机制，并简要回顾了文献。鉴于大多数非典型抗精神病药会导致体重显著增加，尤其是在年轻人群中，因此临床医生应该注意到这种严重的并发症。
