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针对癌症患者通过双重刺激进行卵母细胞取卵的高效方法研究。

Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer.

作者信息

Takeuchi Hiroki, Maezawa Tadashi, Hagiwara Katsuyuki, Horage Yuki, Hanada Tetsuro, Haipeng Huang, Sakamoto Mito, Nishioka Mikiko, Takayama Erina, Terada Kento, Kondo Eiji, Takai Yasushi, Suzuki Nao, Ikeda Tomoaki

机构信息

Department of Obstetrics and Gynecology, Graduate School of Medicine Mie University Tsu Japan.

Department of Education Faculty, Graduate School Mie University Tsu Japan.

出版信息

Reprod Med Biol. 2023 Aug 17;22(1):e12534. doi: 10.1002/rmb2.12534. eCollection 2023 Jan-Dec.

DOI:10.1002/rmb2.12534
PMID:37601482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10433114/
Abstract

PURPOSE

To examine the optimal timing of second ovarian stimulation using the dual stimulation method for good ovarian responders with cancer undergoing oocyte retrieval for fertility preservation.

METHODS

A retrospective analysis was conducted using data from 69 patients with cancer who underwent oocyte retrieval for fertility preservation at four Japanese institutions during 2010-2021. Twenty-two patients underwent two oocyte retrievals for fertility preservation. We studied the relationship between the initial number of oocytes retrieved via dual stimulation and risk of ovarian enlargement as well as the appropriate waiting interval between the end of the first ovarian stimulation and beginning of the second ovarian stimulation.

RESULTS

The risk of ovarian enlargement was high when the initial number of oocytes retrieved via dual stimulation was ≥5. An 8-day waiting interval may be more effective for performing a second ovarian stimulation oocyte retrieval in these cases, although the difference was not significant.

CONCLUSIONS

This study provides one policy for effectively managing ovarian enlargement and timing of second ovarian stimulation during oocyte retrieval via the dual stimulation method for patients with cancer undergoing fertility preservation. If more facilities implement this procedure, more oocytes may be obtained in a short period for fertility preservation purposes.

摘要

目的

探讨采用双重刺激法对癌症患者进行生育力保存卵母细胞采集时，第二次卵巢刺激的最佳时机，这些患者为卵巢反应良好者。

方法

对2010年至2021年期间在日本四家机构接受生育力保存卵母细胞采集的69例癌症患者的数据进行回顾性分析。22例患者接受了两次生育力保存卵母细胞采集。我们研究了通过双重刺激首次采集的卵母细胞数量与卵巢增大风险之间的关系，以及第一次卵巢刺激结束至第二次卵巢刺激开始之间的适当等待间隔。

结果

通过双重刺激首次采集的卵母细胞数量≥5个时，卵巢增大的风险较高。在这些情况下，8天的等待间隔可能对进行第二次卵巢刺激卵母细胞采集更有效，尽管差异不显著。

结论

本研究为通过双重刺激法对癌症患者进行生育力保存卵母细胞采集时，有效管理卵巢增大和第二次卵巢刺激的时机提供了一种策略。如果更多机构实施该程序，可能会在短时间内获得更多卵母细胞用于生育力保存目的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/526c1115117a/RMB2-22-e12534-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/59c75d56c714/RMB2-22-e12534-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/7b9957864cc1/RMB2-22-e12534-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/cf5a3bb38199/RMB2-22-e12534-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/526c1115117a/RMB2-22-e12534-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/59c75d56c714/RMB2-22-e12534-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/7b9957864cc1/RMB2-22-e12534-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/cf5a3bb38199/RMB2-22-e12534-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/185f/10433114/526c1115117a/RMB2-22-e12534-g002.jpg

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本文引用的文献

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Hum Reprod Update. 2022 May 2;28(3):400-416. doi: 10.1093/humupd/dmac003.
2
Preserving Oocytes in Oncofertility†.在肿瘤生育力保护中保存卵母细胞。
Biol Reprod. 2022 Feb 22;106(2):328-337. doi: 10.1093/biolre/ioac008.
3
Double or dual stimulation in poor ovarian responders: where do we stand?
卵巢低反应者的双重或双刺激：我们目前的状况如何？
Ther Adv Reprod Health. 2021 Jun 30;15:26334941211024172. doi: 10.1177/26334941211024172. eCollection 2021 Jan-Dec.
4
Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers.冷冻卵巢组织移植在 285 名女性中的应用：五个欧洲主要中心的回顾性研究。
Fertil Steril. 2021 May;115(5):1102-1115. doi: 10.1016/j.fertnstert.2021.03.008.
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Oocyte vitrification for fertility preservation for both medical and nonmedical reasons.因医学和非医学原因进行的卵母细胞玻璃化冷冻以保存生育力。
Fertil Steril. 2021 May;115(5):1091-1101. doi: 10.1016/j.fertnstert.2021.02.006.
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Factors Associated with Ovarian Hyperstimulation Syndrome (OHSS) Severity in Women With Polycystic Ovary Syndrome Undergoing IVF/ICSI.多囊卵巢综合征患者行体外受精/卵胞浆内单精子注射后卵巢过度刺激综合征严重程度的相关因素。
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