Engelhardt J, Joo F
J Neuroimmunol. 1986 Oct;12(4):279-90. doi: 10.1016/0165-5728(86)90034-2.
Guinea pigs were immunized with motor neurons from swine spinal cords. One month after the last of five serial immunizations, the recipients showed progressive weight loss. By seven months of age, five of the six immunized animals had died. Pathological examination showed destruction of motor neurons in the spinal cords without demyelination, but with atrophy of the related skeletal muscle groups. By immunofluorescent and histochemical tests, serum from the guinea pigs was shown to react with motor neurons of swine and guinea pig cord. This experimental disorder of guinea pigs appeared to be based on the immunologically mediated destruction of motor neurons and it may serve as a model for the human motor neuron diseases.
用猪脊髓运动神经元对豚鼠进行免疫。在连续五次免疫中的最后一次免疫后一个月，接受免疫的豚鼠出现体重逐渐减轻。到七个月龄时，六只免疫动物中有五只死亡。病理检查显示脊髓运动神经元遭到破坏，无脱髓鞘现象，但相关骨骼肌群出现萎缩。通过免疫荧光和组织化学检测，发现豚鼠血清与猪和豚鼠脊髓的运动神经元发生反应。豚鼠的这种实验性病症似乎是基于免疫介导的运动神经元破坏，它可能可作为人类运动神经元疾病的一个模型。
