格雷夫斯病中的脂联素水平——系统评价与荟萃分析

ADIPONECTIN LEVELS IN GRAVES' DISEASE - SYSTEMATIC REVIEW AND META-ANALYSIS.

作者信息

Ismaiel A, Abunahleh A L, Elsayed A, Leucuţa D C, Popa S L, Ismaiel M, Dumitrascu D L

机构信息

"Iuliu Hațieganu" University of Medicine and Pharmacy, 2 Department of Internal Medicine, Cluj-Napoca, Ireland.

"Iuliu Hațieganu" University of Medicine and Pharmacy, Faculty of Medicine, Cluj-Napoca, Ireland.

出版信息

Acta Endocrinol (Buchar). 2023 Jan-Mar;19(1):87-98. doi: 10.4183/aeb.2023.87. Epub 2023 Aug 14.

DOI:10.4183/aeb.2023.87

PMID:37601709

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10439329/

Abstract

CONTEXT

Graves' disease is the most prevalent cause of hyperthyroidism worldwide. Adiponectin, the most abundant adipokine, plays a significant role in a cluster of prevalent diseases connected to metabolic disorders.

OBJECTIVE

Although the association between adiponectin and Graves' disease has been studied, the existing data is inconsistent. Therefore, we conducted this systematic review and meta-analysis to evaluate the relationship between adiponectin levels and Graves' disease.

METHODS

We performed a systematic electronic search on PubMed, EMBASE, Scopus and Cochrane Library using predefined keywords. We used the NHLBI quality assessment tools to assess the included studies.

RESULTS

There were 11 studies involving 781 subjects included in our qualitative synthesis, while 6 studies were included in our quantitative synthesis. We observed significantly increased adiponectin levels in Graves' disease patients compared to controls (MD 2.983 [95% CI 0.138-5.828]) and hypothyroidism patients (MD 3.389 [95% CI 1.332-5.446]). Nevertheless, no significant MD was observed when comparing Graves' disease patients with and without Graves' ophthalmopathy (MD -27.124 [95% CI -88.893 - 34.645]).

CONCLUSIONS

Adiponectin levels were significantly higher in patients with Graves' disease compared to controls and hypothyroidism patients. However, patients with and without Graves' ophthalmopathy did not present a significant mean difference in adiponectin levels.

摘要

背景

格雷夫斯病是全球范围内甲状腺功能亢进最常见的病因。脂联素是最丰富的脂肪因子，在一系列与代谢紊乱相关的常见疾病中发挥着重要作用。

目的

尽管已经对脂联素与格雷夫斯病之间的关联进行了研究，但现有数据并不一致。因此，我们进行了这项系统评价和荟萃分析，以评估脂联素水平与格雷夫斯病之间的关系。

方法

我们使用预定义的关键词在PubMed、EMBASE、Scopus和Cochrane图书馆进行了系统的电子检索。我们使用美国国立心肺血液研究所（NHLBI）的质量评估工具来评估纳入的研究。

结果

我们的定性综合分析纳入了11项研究，涉及781名受试者，而定量综合分析纳入了6项研究。我们观察到，与对照组（MD 2.983 [95% CI 0.138 - 5.828]）和甲状腺功能减退患者（MD 3.389 [95% CI 1.332 - 5.446]）相比，格雷夫斯病患者的脂联素水平显著升高。然而，在比较有无格雷夫斯眼病的格雷夫斯病患者时，未观察到显著的MD（MD -27.124 [95% CI -88.893 - 34.645]）。