Katsuya Hiroo, Nakamura Hideaki, Maeda Aya, Ishii Keitaro, Nagaie Toshiaki, Sano Haruhiko, Sano Haruna, Itamura Hidekazu, Okamoto Sho, Ando Toshihiko, Watanabe Toshiki, Uchimaru Kaoru, Satou Yorifumi, Sueoka Eisaburo, Kimura Shinya
Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan.
Department of Transfusion Medicine Saga University Hospital Saga Japan.
EJHaem. 2023 May 26;4(3):733-737. doi: 10.1002/jha2.725. eCollection 2023 Aug.
Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus-associated tumors. We investigated whether the amount of cfDNA of human T-cell leukemia virus type 1 (HTLV-1) correlates with disease state in adult T-cell leukemia-lymphoma (ATL). HTLV-1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV-1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV-1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones.
血浆中的病毒游离DNA（cfDNA）已被广泛用于检测病毒相关肿瘤中的癌症和监测疾病。我们研究了1型人类T细胞白血病病毒（HTLV-1）的cfDNA量是否与成人T细胞白血病淋巴瘤（ATL）的疾病状态相关。侵袭性ATL中的HTLV-1 cfDNA显著高于惰性ATL和无症状携带者。值得注意的是，淋巴瘤型患者的HTLV-1 cfDNA量高于慢性和冒烟型亚型，尽管他们外周血中没有异常淋巴细胞。HTLV-1 cfDNA可以作为反映ATL克隆扩增的通用生物标志物。
