Sundareswaran Gayatri, Arora Neha, Sankarasubramaniam Anandan
Department of Ophthalmology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Department of Dermatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Oman J Ophthalmol. 2023 Apr 26;16(2):326-328. doi: 10.4103/ojo.ojo_46_22. eCollection 2023 May-Aug.
An 18-year-old male diagnosed with acrodermatitis enteropathica (AE) since early childhood presented with worsening of dermatitis along with photophobia and watering in both eyes. Systemic evaluation by dermatology and gastroenterology specialists confirmed a diagnosis of acute exacerbation of AE, and oral zinc supplements were initiated. A best-corrected visual acuity of 20/20 was documented in both eyes. Slit-lamp examination revealed bilateral subepithelial corneal opacities in a radial fan-like pattern extending from the superior limbus toward the center. A whorled appearance of fluorescein staining and small epithelial erosions was noted in both eyes. Ocular involvements in AE such as blepharitis, cataracts, and radial corneal opacities have been reported previously. We report a new association of AE with limbal stem cell deficiency with its classical features of linear subepithelial corneal opacities with a whorling uptake of fluorescein stain and corneal erosions.
一名自幼儿期就被诊断为肠病性肢端皮炎（AE）的18岁男性，出现了皮炎加重，同时伴有畏光和双眼流泪。皮肤科和胃肠病学专家进行的全身评估确诊为AE急性加重，并开始口服补锌治疗。双眼最佳矫正视力记录为20/20。裂隙灯检查发现双侧角膜上皮下混浊呈放射状扇形，从角膜上缘向中央延伸。双眼均可见荧光素染色呈漩涡状外观及小的上皮糜烂。此前已有报道AE可出现眼部受累，如睑缘炎、白内障和角膜放射状混浊。我们报告了AE与角膜缘干细胞缺乏的一种新关联，其具有角膜上皮下线性混浊、荧光素染色呈漩涡状摄取及角膜糜烂等典型特征。
