Welling P G
J Clin Pharmacol. 1986 Sep-Oct;26(7):510-4. doi: 10.1002/j.1552-4604.1986.tb02943.x.
A considerable amount of information regarding the kinetics of drug absorption, distribution, metabolism, and excretion can be obtained by graphic analysis of plasma concentration and/or urinary excretion data. The simplest pharmacokinetic model is used to describe the analysis of drug concentration profiles in plasma after administration intravenous or nonvascular routes. Methods to calculate pharmacokinetic and pharmacologic parameters include urinary excretion rate, cumulative excretion, and the construction and analysis of Sigma-minus plots. The treatment for this simple pharmacokinetic model provides a basis for graphic analysis of more complex models.
通过对血浆浓度和/或尿排泄数据进行图形分析,可以获得大量有关药物吸收、分布、代谢和排泄动力学的信息。最简单的药代动力学模型用于描述静脉内或非血管途径给药后血浆中药物浓度曲线的分析。计算药代动力学和药理学参数的方法包括尿排泄率、累积排泄量以及Sigma减图的构建和分析。对这种简单药代动力学模型的处理为更复杂模型的图形分析提供了基础。