药代动力学中的统计矩
Statistical moments in pharmacokinetics.
作者信息
Yamaoka K, Nakagawa T, Uno T
出版信息
J Pharmacokinet Biopharm. 1978 Dec;6(6):547-58. doi: 10.1007/BF01062109.
PMID:731417
Abstract
Statistical moments are parameters that describe the characteristics of the time courses of plasma concentration (area, mean residence time, and variance of residence time) and of the urinary excretion rate that follow administration of a single dose of a drug. The relationship between the moments of a time-course curve and pharmacokinetic profiles of drug disposition, i.e., absorption, distribution, metabolism, and excretion, is described. The moments are related to the extent and rate of bioavailability, and it is shown that they can be effectively applied to the deconvolution operation.
摘要
统计矩是描述单次给药后血浆浓度（面积、平均驻留时间和驻留时间方差）以及尿排泄率随时间变化过程特征的参数。文中描述了时程曲线的矩与药物处置（即吸收、分布、代谢和排泄）的药代动力学特征之间的关系。这些矩与生物利用度的程度和速率相关，并且表明它们可有效地应用于反卷积运算。
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