血清 S100 钙结合蛋白 A12 浓度在社区获得性肺炎患者中的临床意义。
Clinical significance of serum S100 calcium-binding protein A12 concentrations in patients with community-acquired pneumonia.
机构信息
Department of Respiratory and Critical Care Medicine, Xichang People's Hospital, Xichang City, Sichuan Province, China.
Department of Pharmacy, Xichang People's Hospital, Xichang City, Sichuan Province, China.
出版信息
J Int Med Res. 2023 Aug;51(8):3000605231191021. doi: 10.1177/03000605231191021.
OBJECTIVE
This study aimed to investigate the clinical significance of serum S100 calcium-binding protein A12 (S100A12) concentrations in patients with community-acquired pneumonia (CAP).
METHODS
This was a case-control study. We selected 120 patients with CAP treated in Xichang People's Hospital from January to June 2022 as the case group. Sixty healthy adults without a history of basic diseases were selected as the control group. The patients in the case group were divided into the low S100A12 and high S100A12 subgroups. Serum S100A12, C-reactive protein (CRP), and procalcitonin (PCT) concentrations, the leukocyte count, and other study parameters were compared.
RESULTS
Serum S100A12, CRP, and PCT concentrations and the leukocyte count were higher in the case group than in the control group. The baseline confusion, urea, respiratory rate, blood pressure, and age ≥ 65 score, baseline pneumonia severity index score, and 30-day mortality rate were higher in the high S100A12 subgroup than in the low S100A12 subgroup. Serum CRP and PCT concentrations and the leukocyte count were higher in the high S100A12 subgroup than in the low S100A12 subgroup.
CONCLUSION
Patients with high serum S100A12 concentrations have more severe CAP, a more serious inflammatory reaction, and higher 30-day mortality.
目的
本研究旨在探讨血清 S100 钙结合蛋白 A12（S100A12）浓度在社区获得性肺炎（CAP）患者中的临床意义。
方法
这是一项病例对照研究。我们选择了 2022 年 1 月至 6 月在西昌人民医院治疗的 120 例 CAP 患者作为病例组。选择 60 名无基础疾病史的健康成年人作为对照组。将病例组患者分为低 S100A12 组和高 S100A12 组。比较血清 S100A12、C 反应蛋白（CRP）和降钙素原（PCT）浓度、白细胞计数等研究参数。
结果
病例组血清 S100A12、CRP 和 PCT 浓度及白细胞计数均高于对照组。高 S100A12 组的基线意识障碍、尿素、呼吸频率、血压、年龄≥65 分、基线肺炎严重指数评分和 30 天死亡率均高于低 S100A12 组。高 S100A12 组血清 CRP 和 PCT 浓度及白细胞计数均高于低 S100A12 组。
结论
血清 S100A12 浓度较高的患者 CAP 更严重，炎症反应更严重，30 天死亡率更高。
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