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一份关于左卵巢纤维卵泡膜细胞瘤经腹腔镜切除后十年复发的两例病例报告。

A case report of two pelviscopic resections of fibrothecomas originating from the left ovary with recurrence after ten years.

机构信息

Department of Obstetrics and Gynecology, Cheonan-city, Chungnam, Korea.

Pathology, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

出版信息

Medicine (Baltimore). 2023 Aug 18;102(33):e34880. doi: 10.1097/MD.0000000000034880.

Abstract

RATIONALE

Fibrothecomas are benign ovarians tumors. These are solid sex-cord-stromal tumors, accounting for 1% to 4.7% of all ovarian neoplasms. Their recurrence rate is known to be only 2% following ovarian sparing local mass excision. We report an uncommon case of 2 pelviscopic resections of fibrothecomas originating from the left ovary with recurrence after 10 years in a 34-year-old woman.

PATIENT CONCERNS

A 34-year-old married woman was diagnosed with 41 mm sized left ovarian recurrent fibrothecoma. We performed mass excision pelviscopically the first time 10 years ago. She gave birth to her second baby at 7 years after the first surgery. Ten years after the first surgery, fibrothecoma recurred on the same ovary with size larger than before.

DIAGNOSES

At the time of its first occurrence 10 years ago, the ultrasound scan revealed a 34 × 23 mm-sized solid hypoechoic mass with well-demarcated margins and minimal Doppler flows. Ultrasound findings at the time of recurrence 10 years later showed the same findings, with its size increased to 41 × 40 mm. Final pathologic findings showed left ovarian fibrothecoma.

INTERVENTIONS

After her admission to the hospital, we performed pelviscopic removal of left ovarian fibroma. Microscopic examination revealed predominantly bland spindle cells with collagenous stroma, showing fascicular and storiform growth.

OUTCOMES

Surgeries were successful. The patient had been followed-up regularly for 3 years after last surgery. She did not experience any complications. She remained disease-free.

LESSONS

Repetitive local mass excision appears to be an effective surgical option in women of reproductive age. Although there is a sufficient possibility of recurrence several years to decades after only mass excision, mass excision is more appropriate than total oophorectomy in women of childbearing age. Pelviscopic surgery is recommended.

摘要

背景

纤维卵泡膜细胞瘤是良性卵巢肿瘤。这些是实性性索-间质肿瘤,占所有卵巢肿瘤的 1%至 4.7%。已知行保留卵巢的局部肿块切除术,其复发率仅为 2%。我们报告了一例罕见的病例,一名 34 岁女性左卵巢纤维卵泡膜细胞瘤行 2 次腹腔镜下切除术,10 年后复发。

病例报告

一名 34 岁已婚女性诊断为左侧卵巢复发性纤维卵泡膜细胞瘤,大小为 41mm。10 年前我们首次行肿块切除术。第一次手术后 7 年,她生下了第二个孩子。第一次手术后 10 年,同侧卵巢的纤维卵泡膜细胞瘤复发,且大小大于前次。

首次就诊时,超声检查显示边界清楚的 34×23mm 大小的实性低回声肿块,血流较少。10 年后复发时的超声表现相同,大小增加至 41×40mm。最终病理结果显示左侧卵巢纤维卵泡膜细胞瘤。

干预措施

患者入院后,我们行腹腔镜下左卵巢纤维瘤切除术。显微镜下观察主要为良性梭形细胞伴胶原基质,呈束状和席纹状生长。

结果

手术成功。最后一次手术后,患者定期随访 3 年,无任何并发症。她仍然没有疾病。

结论

对于育龄妇女,重复局部肿块切除术似乎是一种有效的手术选择。虽然在仅行肿块切除术后的数年内甚至数十年后有足够的复发可能,但在育龄妇女中,肿块切除术比卵巢切除术更合适。推荐行腹腔镜手术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/262b/10443753/6c9ee2045928/medi-102-e34880-g001.jpg

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