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不同镇痛治疗对老年髋部骨折患者肺功能的影响:一项前瞻性研究。

Effect of different analgesic treatments on the pulmonary function in elderly hip fracture patients: A prospective study.

机构信息

Department of Anesthesiology, 958 Hospital of Army, Chongqing, China.

出版信息

Medicine (Baltimore). 2023 Aug 18;102(33):e34505. doi: 10.1097/MD.0000000000034505.

Abstract

BACKGROUND

To investigate the effect of different analgesic methods on lungs in elderly patients with hip fractures.

METHODS

A prospective study was conducted on 78 elderly hip fracture patients undergoing spinal anesthesia for surgery, where 3 analgesic methods were used: postoperative Patient-controlled intravenous analgesia pump (PCIA) (group I), pre and postoperative PCIA (group II), and preoperative fascia iliaca compartment block (FICB) + postoperative PCIA (group III). The following indicators were monitored at admission (T1), on the day of surgery before anesthesia (T2), and 7 days after surgery (T3): heart rate (HR), respiratory rate (RR), forced expiratory volume during the first second, arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2), C-reactive protein (CRP), and interleukin 6 (IL-6). Pulmonary complications such as pulmonary atelectasis and respiratory insufficiency were analyzed.

RESULTS

The HR, RR, forced expiratory volume during the first second, PaO2, PaCO2, IL-6, and CRP levels at T1 after fracture did not significantly differ among the 3 groups (P > .05). After different analgesic treatments post-admission, all indicators at T2 were significantly higher in group I than in groups II and III (P < .05), while there was no significant difference between groups II and III (P > .05). At T3, there were no significant differences in RR, HR, PaO2, PaCO2, and CRP levels among the groups (P > .05), but IL-6 levels at T3 were significantly higher in group I than in groups II and III (P < .05).

CONCLUSION

The use of effective pain relief during surgery can help protect the lung function of elderly patients with hip fractures. When using PCIA with FICB before surgery, respiratory performance may be better protected compared to using unsustained analgesia. This could be due to a decrease in the levels of inflammatory markers such as CRP and interleukin-6.

摘要

背景

探讨不同镇痛方法对老年髋部骨折患者肺部的影响。

方法

对 78 例行椎管内麻醉手术的老年髋部骨折患者进行前瞻性研究,采用 3 种镇痛方法:术后患者自控静脉镇痛泵(PCIA)(I 组)、术前和术后 PCIA(II 组)和术前股外侧肌筋膜间隔阻滞(FICB)+术后 PCIA(III 组)。在入院时(T1)、麻醉前手术当天(T2)和手术后 7 天(T3)监测以下指标:心率(HR)、呼吸频率(RR)、第 1 秒用力呼气量、动脉血氧分压(PaO2)和二氧化碳分压(PaCO2)、C 反应蛋白(CRP)和白细胞介素 6(IL-6)。分析肺部并发症,如肺不张和呼吸功能不全。

结果

骨折后 T1 时,3 组的 HR、RR、第 1 秒用力呼气量、PaO2、PaCO2、IL-6 和 CRP 水平无显著差异(P>.05)。入院后采用不同镇痛治疗后,I 组 T2 时所有指标均显著高于 II 组和 III 组(P<.05),而 II 组和 III 组之间无显著差异(P>.05)。T3 时,各组 RR、HR、PaO2、PaCO2 和 CRP 水平无显著差异(P>.05),但 I 组 T3 时 IL-6 水平显著高于 II 组和 III 组(P<.05)。

结论

手术期间采用有效的止痛方法有助于保护老年髋部骨折患者的肺功能。与持续镇痛相比,术前使用 PCIA 联合 FICB 时,呼吸功能可能得到更好的保护,这可能是由于 CRP 和白细胞介素-6 等炎症标志物水平降低所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f82/10443746/ecb63d14a178/medi-102-e34505-g001.jpg

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