West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
Ecotoxicol Environ Saf. 2023 Sep 15;263:115384. doi: 10.1016/j.ecoenv.2023.115384. Epub 2023 Aug 19.
BACKGROUND: Ambient particulate matter with aerodynamic diameter ≤ 2.5 µm (PM) consists of various toxic constituents. However, the health effect of PM may differ depending on its constituents, but the joint effect of PM constituents remains incompletely understood. OBJECTIVE: Our goal was to evaluate the joint effect of long-term PM constituent exposures on dyslipidemia and identify the most hazardous chemical constituent. METHODS: This study included 67,015 participants from the China Multi-Ethnic Cohort study. The average yearly levels of PM constituents for all individuals at their residences were assessed through satellite remote sensing and chemical transport modeling. Dyslipidemia was defined as one or more following abnormal blood lipid concentrations: total cholesterol (TC) ≥ 6.22 mmol/L, triglycerides (TG) ≥ 2.26 mmol/L, high-density lipoprotein cholesterol (HDL-C) < 1.04 mmol/L, and low-density lipoprotein cholesterol (LDL-C) ≥ 4.14 mmol/L. The logistic regression model was utilized to examine the single effect of PM2.5 constituents on dyslipidemia, while the weighted quantile sum regression model for the joint effect. RESULTS: The odds ratio with a 95 % confidence interval for dyslipidemia positively related to per-SD increase in the three-year average was 1.29 (1.20-1.38) for PM mass, 1.25 (1.17-1.34) for black carbon, 1.24 (1.16-1.33) for ammonium, 1.33 (1.24-1.43) for nitrate, 1.34 (1.25-1.44) for organic matter, 1.15 (1.08-1.23) for sulfate, 1.30 (1.22-1.38) for soil particles, and 1.12 (1.05-1.92) for sea salt. Stronger associations were observed in individuals < 65 years of age, males, and those with low physical activity. Joint exposure to PM constituents was positively related to dyslipidemia (OR: 1.09, 95 %CI: 1.05-1.14). Nitrate was identified as the constituent with the largest weight (weighted at 0.387). CONCLUSIONS: Long-term exposure to PM constituents poses a significant risk to dyslipidemia and nitrate might be the most responsible for the risk. These findings indicate that reducing PM constituent exposures, especially nitrate, could be beneficial to alleviate the burden of disease attributed to PM-related dyslipidemia.
背景：空气动力学直径≤2.5μm 的环境颗粒物（PM）由各种有毒成分组成。然而，PM 的健康影响可能因成分而异，但 PM 成分的联合效应仍不完全清楚。
目的：我们的目标是评估长期 PM 成分暴露对血脂异常的联合影响，并确定最危险的化学成分。
方法：本研究纳入了来自中国多民族队列研究的 67015 名参与者。通过卫星遥感和化学输送模型评估所有个体居住地的 PM 成分的平均年水平。血脂异常定义为以下一种或多种异常血脂浓度：总胆固醇（TC）≥6.22mmol/L，甘油三酯（TG）≥2.26mmol/L，高密度脂蛋白胆固醇（HDL-C）<1.04mmol/L 和低密度脂蛋白胆固醇（LDL-C）≥4.14mmol/L。利用逻辑回归模型检验 PM2.5 成分对血脂异常的单因素影响，而利用加权分位数和回归模型检验联合影响。
结果：与 PM 质量、黑碳、铵、硝酸盐、有机物、硫酸盐、土壤颗粒和海盐的三年平均每标准差增加相关的血脂异常比值比（OR）分别为 1.29（1.20-1.38）、1.25（1.17-1.34）、1.24（1.16-1.33）、1.33（1.24-1.43）、1.34（1.25-1.44）、1.15（1.08-1.23）、1.30（1.22-1.38）和 1.12（1.05-1.92）。在年龄<65 岁、男性和体力活动水平较低的个体中观察到更强的关联。PM 成分的联合暴露与血脂异常呈正相关（OR：1.09，95%CI：1.05-1.14）。硝酸盐被确定为权重最大的成分（权重为 0.387）。
结论：长期暴露于 PM 成分会显著增加血脂异常的风险，而硝酸盐可能是导致这种风险的主要原因。这些发现表明，减少 PM 成分的暴露，特别是硝酸盐的暴露，可能有助于减轻与 PM 相关的血脂异常相关的疾病负担。
Ecotoxicol Environ Saf. 2023-9-15
Ecotoxicol Environ Saf. 2023-9-15
Ecotoxicol Environ Saf. 2022-10-15
Sci Total Environ. 2023-2-10
Environ Pollut. 2024-1-15
J Allergy Clin Immunol. 2022-7
Curr Environ Health Rep. 2023-12
Zotero 插件