Department of Orthopedics, People's Hospital of Deyang City, Deyang, China.
Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Ann Med. 2023;55(2):2249018. doi: 10.1080/07853890.2023.2249018.
The association between inflammation and venous thromboembolism (VTE) has attracted increasing research interest. Recently, the systemic inflammation response index (SIRI) has been proposed as a novel inflammatory biomarker, but its potential association with lower extremity deep venous thrombosis (LEDVT) has not been investigated. Thus, this study aimed to explore the association between SIRI and LEDVT risk in a large sample over a 10-year period (2012-2022).
All hospitalized patients who underwent lower extremity compression ultrasonography (CUS) examinations were consecutively identified from our hospital information system database. Multivariate logistic regression analysis was used to investigate the association between SIRI and LEDVT risk. Sensitivity, restricted cubic spline and subgroup analyses were also performed.
In total, 12643 patients were included, and 1346 (10.6%) LEDVT events occurred. After full adjustment, a higher SIRI level was significantly associated with an increased risk of LEDVT (odds ratio [OR] = 1.098, 95% confidence interval []: 1.068-1.128, < 0.001), and patients in quartile 4 had a 2.563-fold higher risk of LEDVT than those in quartile 1 (95% : 2.064-3.182, < 0.001). A nonlinear relationship was observed ( for nonlinearity < 0.001), with an inflection point of 4.17. Below this point, each unit increase in SIRI corresponded to a 35.3% increase in LEDVT risk (95% : 1.255-1.458, < 0.001). No significant difference was found above the inflection point (OR = 1.015, 95% : 0.963-1.069, = 0.582). Sensitivity and subgroup analyses confirmed the robustness of the association. This association also existed in both distal and proximal LEDVT.
A High SIRI is significantly associated with an increased risk of LEDVT in hospitalized patients. Given that the SIRI is a readily available biomarker in clinical settings, its potential clinical use deserves further exploration.
炎症与静脉血栓栓塞症（VTE）之间的关联引起了越来越多的研究兴趣。最近，全身性炎症反应指数（SIRI）被提出作为一种新的炎症生物标志物，但它与下肢深静脉血栓形成（LEDVT）的潜在关联尚未得到研究。因此，本研究旨在探讨 SIRI 与 10 年间（2012-2022 年）住院患者 LEDVT 风险之间的关系。
从我院的信息系统数据库中连续确定所有接受下肢压迫超声检查的住院患者。采用多变量逻辑回归分析来探讨 SIRI 与 LEDVT 风险之间的关系。还进行了敏感性、限制性立方样条和亚组分析。
共纳入 12643 例患者，发生 1346 例（10.6%）LEDVT 事件。经完全调整后，较高的 SIRI 水平与 LEDVT 风险增加显著相关（比值比 [OR] = 1.098，95%置信区间 [CI]：1.068-1.128， < 0.001），且 SIRI 四分位 4 组患者的 LEDVT 风险是四分位 1 组的 2.563 倍（95% CI：2.064-3.182， < 0.001）。观察到非线性关系（ for nonlinearity < 0.001），拐点为 4.17。在此点以下，SIRI 每增加一个单位，LEDVT 风险增加 35.3%（95% CI：1.255-1.458， < 0.001）。在此点以上，无显著差异（OR = 1.015，95% CI：0.963-1.069， = 0.582）。敏感性和亚组分析证实了该关联的稳健性。该关联在远端和近端 LEDVT 中均存在。
高 SIRI 与住院患者 LEDVT 风险增加显著相关。鉴于 SIRI 是临床中易于获得的生物标志物，其潜在的临床应用值得进一步探索。
