The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
Department of Global Health, University of Washington, Seattle, Washington.
Am J Trop Med Hyg. 2023 Aug 21;109(4):830-834. doi: 10.4269/ajtmh.23-0176. Print 2023 Oct 4.
Mass drug administration (MDA) is a key strategy for the control of soil-transmitted helminths (STHs). Within MDA programs, poor and non-random compliance threaten successful control of STHs. A case-control study was conducted comparing perceptions among non-compliant participants with compliant participants during a community-wide MDA (cMDA) with albendazole in southern India. Common reasons cited for non-compliance were that the individual was not infected with STH (97.4%), the perception that he/she was healthy (91%), fear of side-effects (12.8%), and dislike of consuming tablets (10.3%). Noncompliance was associated with poor awareness of intestinal worms (odds ratio [OR]: 9.63, 95% CI: 2.11-43.84), the perception that cMDA was only required for those with worms (OR: 2.14, 95% CI: 1.06-4.36), and the perception that the drug is not safe during pregnancy (OR: 2.19, 95% CI: 1.18-4.07) or when on concomitant medications (OR: 3.14, 95% CI: 1.38-7.15). Understanding of perceptions driving noncompliance can provide valuable insights to optimize participation during MDA for STHs.
大规模药物驱虫（MDA）是控制土壤传播性蠕虫（STHs）的关键策略。在 MDA 项目中，低参与率和非随机参与率威胁着 STHs 的有效控制。本项病例对照研究比较了印度南部一次社区范围 MDA（cMDA）期间，阿苯达唑治疗中不依从参与者和依从参与者的认知。不依从的常见原因包括个体未感染 STH（97.4%）、个体认为自己健康（91%）、担心副作用（12.8%）和不喜欢服用药片（10.3%）。对肠道蠕虫的认识不足（比值比 [OR]：9.63，95%CI：2.11-43.84）、认为 cMDA 只适用于有蠕虫的人（OR：2.14，95%CI：1.06-4.36）以及认为该药物在怀孕期间或同时服用其他药物时不安全（OR：2.19，95%CI：1.18-4.07）与不依从相关。了解驱动不依从的认知可以为优化 STHs 的 MDA 参与提供有价值的见解。
