库欣综合征患者的血清降钙素水平。

Serum levels of calcitonin in Cushing's syndrome.

作者信息

Luisetto G, Mantero F, Boscaro M, Tizian L, Zangari M, Ziliotto D

出版信息

J Endocrinol Invest. 1986 Jun;9(3):239-41. doi: 10.1007/BF03348108.

Abstract

Serum levels of calcitonin (CT) were studied in 21 patients with Cushing's syndrome (CS), 18 females and 3 males aging from 16 to 59 years, and in 70 age and sex matched normal subjects. Patients with CS showed CT values significantly lower than those found in controls (9.9 +/- 5.0 pg/ml vs. 15.9 +/- 6.3 pg/ml, mean +/- SD; p less than 0.01), while no difference was observed in total serum calcium and phosphate and calcium corrected for albumin. No correlation between CT and serum calcium and phosphate, serum cortisol and urinary free cortisol was found. It is possible that low CT levels are involved in the pathogenesis of bone loss observed in CS.

摘要

对21例库欣综合征（CS）患者（18例女性，3例男性，年龄16至59岁）以及70例年龄和性别匹配的正常受试者的血清降钙素（CT）水平进行了研究。CS患者的CT值显著低于对照组（分别为9.9±5.0 pg/ml和15.9±6.3 pg/ml，均值±标准差；p<0.01），而血清总钙、磷酸盐以及校正白蛋白后的钙水平无差异。未发现CT与血清钙、磷酸盐、血清皮质醇及尿游离皮质醇之间存在相关性。CS中观察到的骨质流失发病机制可能与低CT水平有关。