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Calico Life Sciences LLC, 1170 Veterans Blvd., South San Francisco, CA, 94080, USA.
Sci Rep. 2023 Aug 21;13(1):13554. doi: 10.1038/s41598-023-40738-w.
We present a method to infer the 3D pose of mice, including the limbs and feet, from monocular videos. Many human clinical conditions and their corresponding animal models result in abnormal motion, and accurately measuring 3D motion at scale offers insights into health. The 3D poses improve classification of health-related attributes over 2D representations. The inferred poses are accurate enough to estimate stride length even when the feet are mostly occluded. This method could be applied as part of a continuous monitoring system to non-invasively measure animal health, as demonstrated by its use in successfully classifying animals based on age and genotype. We introduce the Mouse Pose Analysis Dataset, the first large scale video dataset of lab mice in their home cage with ground truth keypoint and behavior labels. The dataset also contains high resolution mouse CT scans, which we use to build the shape models for 3D pose reconstruction.
我们提出了一种从单目视频中推断小鼠 3D 姿势(包括四肢和脚部)的方法。许多人类临床病症及其对应的动物模型都会导致运动异常,而准确地大规模测量 3D 运动可以深入了解健康状况。与 2D 表示相比,3D 姿势可以改善与健康相关属性的分类。即使脚部大部分被遮挡,推断出的姿势也足够准确,可以估计步长。该方法可以作为连续监测系统的一部分,用于非侵入式测量动物健康,如其在基于年龄和基因型成功分类动物方面的应用所示。我们引入了 Mouse Pose Analysis Dataset,这是第一个带有地面真实关键点和行为标签的实验室小鼠在其笼中进行视频的大规模数据集。该数据集还包含高分辨率的小鼠 CT 扫描,我们使用这些扫描来构建 3D 姿势重建的形状模型。