Şimşek Hasan, Küçükler Sefa, Gür Cihan, İleritürk Mustafa, Aygörmez Serpil, Kandemir Fatih Mehmet
Department of Physiology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye.
Department of Veterinary Biochemistry, Faculty of Veterinary, Atatürk University, Erzurum, Türkiye.
Iran J Basic Med Sci. 2023;26(9):1098-1106. doi: 10.22038/IJBMS.2023.71905.15623.
Sodium arsenite (SA) exposure is toxic to the body. Zingerone (ZNG) is a flavonoid with many biological properties found naturally in honey and plants. This study aimed to determine the effects of ZNG on SA-induced rat lung toxicity.
Thirty-five male Sprague rats were divided into Control, SA, ZNG, SA+ZNG25, and SA+ZNG50 groups (n=7). SA 10 mg/kg and ZNG were administered at two doses (25 and 50 mg/kg) (orally, 14 days). Analysis of oxidative stress, inflammation damage, apoptosis damage, and autophagic damage markers in lung tissue were determined by biochemical and histological methods.
The administration of ZNG reduced oxidative stress by increasing SA-induced decreased antioxidant enzyme activities, increasing Nrf-2, HO-1, and NQO1, and decreasing MDA level. ZNG administration reduced inflammation marker levels. Anti-apoptotic Bcl-2 increased and apoptotic Bax and Caspase-3 decreased with ZNG. ZNG promoted the regression of autophagy by reducing Beclin-1, LC3A, and LC3B levels.
Evaluating all data showed that SA caused toxic damage to lung tissue by increasing inflammation, apoptosis, autophagy, and oxidant levels, whereas ZNG had a protective effect by reducing this damage.
亚砷酸钠（SA）暴露对身体有毒性。姜辣素（ZNG）是一种在蜂蜜和植物中天然存在的具有多种生物学特性的类黄酮。本研究旨在确定ZNG对SA诱导的大鼠肺毒性的影响。
将35只雄性Sprague大鼠分为对照组、SA组、ZNG组、SA+ZNG25组和SA+ZNG50组（n=7）。SA 10 mg/kg和ZNG以两种剂量（25和50 mg/kg）给药（口服，14天）。通过生化和组织学方法测定肺组织中氧化应激、炎症损伤、凋亡损伤和自噬损伤标志物。
ZNG给药通过增加SA诱导降低的抗氧化酶活性、增加Nrf-2、HO-1和NQO1以及降低MDA水平来减轻氧化应激。ZNG给药降低了炎症标志物水平。ZNG使抗凋亡蛋白Bcl-2增加，凋亡蛋白Bax和Caspase-3减少。ZNG通过降低Beclin-1、LC3A和LC3B水平促进自噬的消退。
综合所有数据表明，SA通过增加炎症、凋亡、自噬和氧化剂水平对肺组织造成毒性损伤，而ZNG通过减轻这种损伤发挥保护作用。
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