Rackow E C, Janz T, Astiz M E, Weil M H
J Lab Clin Med. 1986 Oct;108(4):349-53.
The effect of decreases in plasma colloid osmotic pressure (COP) on the development of lung edema was studied in nephrotic rats. Five control animals were compared with five animals with nephrotic syndrome induced by administration of anti-rat glomerular basement membrane antibody. The COP and the left ventricular diastolic pressure (LVDP) were significantly decreased in nephrotic rats. However, no significant differences were seen in the COP - LVDP gradient, weight-to-dry lung weight ratio, or arterial oxygenation between the nephrotic and control animals. These data suggest that decreases in COP during nephrosis are not associated with accumulation of extravascular lung water.
在肾病大鼠中研究了血浆胶体渗透压（COP）降低对肺水肿形成的影响。将5只对照动物与5只通过给予抗大鼠肾小球基底膜抗体诱导产生肾病综合征的动物进行比较。肾病大鼠的COP和左心室舒张压（LVDP）显著降低。然而，肾病大鼠与对照动物之间在COP-LVDP梯度、湿重与干肺重比值或动脉氧合方面未观察到显著差异。这些数据表明，肾病期间COP降低与血管外肺水的积聚无关。
