Köksaldı Seher, Nazlı Arzu, Kaya Mahmut, Saatci Ali Osman
Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
Department of Clinical Microbiology and Infectious Diseases, Dokuz Eylul University, Izmir, Turkey.
Int J STD AIDS. 2023 Oct;34(11):817-822. doi: 10.1177/09564624231195674. Epub 2023 Aug 22.
A retrospective analysis of 10 consecutive patients who had serologically confirmed ocular syphilis between June 2020 and February 2023 was performed. All cases presented with ocular manifestations. Eight patients were diagnosed with syphilis and two patients with syphilis/human immunodeficiency virus co-infection. Type and duration of antibiotic treatments were diverse among the patients. Four patients had intramuscular benzyl-penicillin G 2.4 million units (MU) weekly for three weeks; four, intravenous ceftriaxone for 14 days; one, intravenous penicillin G 24 MU/day for 14 days; and the remaining patient, intravenous penicillin G 24 MU/day for a week and then oral doxycycline for two weeks. As adjunctive therapy to systemic antibiotics, oral corticosteroids in three patients and intravitreal ceftazidime (2.25 mg/0.1 mL) injections in one patient were administered. In conclusion, ocular syphilis is a re-emerging phenomenon; prompt diagnosis and proper antibiotic treatment can prevent serious ocular complications.
对2020年6月至2023年2月期间10例血清学确诊的眼梅毒患者进行了回顾性分析。所有病例均有眼部表现。8例患者诊断为梅毒，2例患者诊断为梅毒/人类免疫缺陷病毒合并感染。患者之间抗生素治疗的类型和持续时间各不相同。4例患者每周肌肉注射苄星青霉素G 240万单位，共3周；4例患者静脉注射头孢曲松14天；1例患者静脉注射青霉素G 2400万单位/天，共14天；其余患者静脉注射青霉素G 2400万单位/天，共1周，然后口服多西环素2周。作为全身抗生素的辅助治疗，3例患者使用了口服皮质类固醇，1例患者进行了玻璃体内注射头孢他啶（2.25mg/0.1mL）。总之，眼梅毒是一种再次出现的现象；及时诊断和适当的抗生素治疗可预防严重的眼部并发症。
