免疫学：NACHT 结构域蛋白的原核起源故事。

Immunology: NACHT domain proteins get a prokaryotic origin story.

机构信息

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

出版信息

Curr Biol. 2023 Aug 21;33(16):R875-R878. doi: 10.1016/j.cub.2023.06.084.

DOI:10.1016/j.cub.2023.06.084

PMID:37607487

Abstract

The NACHT domain is found in eukaryotic pattern recognition receptors that promote anti-microbial defense, mediating their oligomerization into immune signaling complexes. Kibby et al. uncover a superfamily of prokaryotic NACHT-containing proteins and demonstrate that some members of this family mediate anti-phage defense.

摘要

NACHT 结构域存在于真核模式识别受体中，促进抗微生物防御，介导它们寡聚化形成免疫信号复合物。Kibby 等人发现了一个原核 NACHT 蛋白的超家族，并证明该家族的一些成员介导抗噬菌体防御。