Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine, Irvine, CA 92697, USA.
Curr Opin Microbiol. 2023 Jun;73:102295. doi: 10.1016/j.mib.2023.102295. Epub 2023 Apr 1.
The innate immune system is the first line of defense against microbial pathogens. Many of the features of eukaryotic innate immunity have long been viewed as lineage-specific innovations, evolved to deal with the challenges and peculiarities of multicellular life. However, it has become increasingly apparent that in addition to evolving their own unique antiviral immune strategies, all lifeforms have some shared defense strategies in common. Indeed, critical fixtures of animal innate immunity bear striking resemblance in both structure and function to the multitude of diverse bacteriophage (phage) defense pathways discovered hidden in plain sight within the genomes of bacteria and archaea. This review will highlight many surprising examples of the recently revealed connections between prokaryotic and eukaryotic antiviral immune systems.
先天免疫系统是抵御微生物病原体的第一道防线。真核生物先天免疫的许多特征长期以来一直被视为谱系特异性创新，是为了应对多细胞生命的挑战和特殊性而进化的。然而，越来越明显的是，除了进化出自己独特的抗病毒免疫策略外，所有生命形式都有一些共同的防御策略。事实上，动物先天免疫的关键组成部分在结构和功能上与在细菌和古菌基因组中显而易见的多种不同噬菌体（噬菌体）防御途径惊人地相似。这篇综述将重点介绍最近发现的原核和真核抗病毒免疫系统之间令人惊讶的许多连接的例子。
