乳制品摄入的血浆脂肪酸生物标志物与墨西哥青少年代谢综合征成分的性别依赖性影响有关。

Plasma Fatty Acid Biomarkers of Dairy Consumption Are Associated with Sex-Dependent Effects on Metabolic Syndrome Components in Mexican Adolescents.

机构信息

Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico,

Health Department, Iberoamerican University, Mexico City, Mexico.

出版信息

Ann Nutr Metab. 2023;79(4):343-354. doi: 10.1159/000531972. Epub 2023 Aug 22.

DOI:10.1159/000531972

PMID:37607502

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10614258/

Abstract

INTRODUCTION

During adolescence, dairy product intake has shown conflicting associations with metabolic syndrome (MetS) components, which are risk factors for cardiovascular disease (CVD). This study aims to investigate the association between plasma fatty acids (FAs) C15:0, C17:0, and t-C16:1n-7, as biomarkers of dairy intake, with MetS and its components in Mexican adolescents.

METHODS

A sample of 311 participants from the Early Life Exposure in Mexico City to Environmental Toxicants (ELEMENT) cohort was included in this cross-sectional analysis. FA concentrations were measured in plasma as a percentage of total FA. We used quantile regression models stratified by sex to evaluate the association between FA quantiles and MetS components, adjusting for age, socioeconomic status (SES), sedentary behavior, BMI z-score, pubertal status, and energy intake.

RESULTS

We found significant associations between dairy biomarkers and the median of MetS variables. In females, t-C16:1n-7 was associated with a decrease of 2.97 cm in WC (Q4 vs. Q1; 95% CI: -5.79, -0.16). In males, C15:0 was associated with an increase of 5.84 mm/Hg in SBP (Q4 vs. Q1; CI: 1.82, 9.85). For HDL-C, we observed opposite associations by sex. C15:0 in males was associated with decreased HDL-C (Q3 vs. Q1: β = -4.23; 95% CI: -7.98, -0.48), while in females, C15:0 and t-C16:1n-7 were associated with increased HDL-C (Q3 vs. Q1: β = 4.75; 95% CI: 0.68, 8.82 and Q4 vs. Q1: β = 6.54; 95% CI: 2.01, 11.07), respectively. Additionally, in both sexes, different levels of C15:0, C17:0, and t-C16:1n-7 were associated with increased triglycerides (TG).

CONCLUSION

Our results suggest that adolescent dairy intake may be associated in different directions with MetS components and that associations are sex-dependent.

摘要

简介

在青少年时期，乳制品的摄入量与代谢综合征（MetS）的各个组成部分有关，而这些组成部分是心血管疾病（CVD）的危险因素。本研究旨在探讨墨西哥青少年体内血浆脂肪酸（FAs）C15:0、C17:0 和 t-C16:1n-7 作为乳制品摄入生物标志物与 MetS 及其组成部分之间的关联。

方法

本横断面分析纳入了早期生活暴露于墨西哥城环境毒素（ELEMENT）队列的 311 名参与者。FA 浓度以总 FA 的百分比在血浆中进行测量。我们使用按性别分层的分位数回归模型来评估 FA 分位数与 MetS 成分之间的关联，调整了年龄、社会经济地位（SES）、久坐行为、BMI z 评分、青春期状态和能量摄入。

结果

我们发现乳制品生物标志物与 MetS 变量中位数之间存在显著关联。在女性中，t-C16:1n-7 与 WC 的减少有关（Q4 与 Q1 相比；95%CI：-5.79，-0.16）。在男性中，C15:0 与 SBP 的增加有关（Q4 与 Q1 相比；CI：1.82，9.85）。对于 HDL-C，我们观察到性别之间的相反关联。男性的 C15:0 与 HDL-C 降低有关（Q3 与 Q1 相比：β=-4.23；95%CI：-7.98，-0.48），而在女性中，C15:0 和 t-C16:1n-7 与 HDL-C 升高有关（Q3 与 Q1 相比：β=4.75；95%CI：0.68，8.82 和 Q4 与 Q1 相比：β=6.54；95%CI：2.01，11.07）。此外，在两性中，C15:0、C17:0 和 t-C16:1n-7 的不同水平与甘油三酯（TG）的升高有关。