咪达唑仑作为抗癫痫化合物的药效学评价。
A pharmacodynamic evaluation of midazolam as an antiepileptic compound.
作者信息
Jawad S, Oxley J, Wilson J, Richens A
出版信息
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1050-4. doi: 10.1136/jnnp.49.9.1050.
Abstract
Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration. It is currently used for pre-medication and the induction of anaesthesia. Its antiepileptic properties have been evaluated by studying its effect on interictal spikes on the EEG of six adult epileptic patients. The results indicate that intramuscular midazolam 15 mg is more effective than intramuscular diazepam 10 mg in abolishing interictal spikes and as effective as intravenous diazepam 20 mg five minutes after administration.
摘要
咪达唑仑是一种水溶性的1,4 - 苯二氮䓬类药物，适用于肌肉注射。它目前用于术前用药和麻醉诱导。通过研究其对6名成年癫痫患者脑电图发作间期棘波的影响，对其抗癫痫特性进行了评估。结果表明，肌肉注射15毫克咪达唑仑在消除发作间期棘波方面比肌肉注射10毫克地西泮更有效，且在给药五分钟后与静脉注射20毫克地西泮效果相同。
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