Tyumina Elena, Subbotina Maria, Polygalov Maxim, Tyan Semyon, Ivshina Irina
Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences, Perm, Russia.
Microbiology and Immunology Department, Perm State University, Perm, Russia.
Front Microbiol. 2023 Aug 7;14:1200108. doi: 10.3389/fmicb.2023.1200108. eCollection 2023.
Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises concerns for ecological well-being. It poses a growing threat due to its racemic mixture, enantiomers, and transformation products, which have ecotoxicological effects on various organisms, including invertebrates, vertebrates, plants, and microorganisms. Furthermore, ketoprofen is bioaccumulated and biomagnified throughout the food chain, threatening the ecosystem function. Surprisingly, despite these concerns, ketoprofen is not currently considered a priority substance. While targeted eco-pharmacovigilance for ketoprofen has been proposed, data on ketoprofen as a pharmaceutical contaminant are limited and incomplete. This review aims to provide a comprehensive summary of the most recent findings (from 2017 to March 2023) regarding the global distribution of ketoprofen in the environment, its ecotoxicity towards aquatic animals and plants, and available removal methods. Special emphasis is placed on understanding how ketoprofen affects microorganisms that play a pivotal role in Earth's ecosystems. The review broadly covers various approaches to ketoprofen biodegradation, including whole-cell fungal and bacterial systems as well as enzyme biocatalysts. Additionally, it explores the potential of adsorption by algae and phytoremediation for removing ketoprofen. This review will be of interest to a wide range of readers, including ecologists, microbiologists, policymakers, and those concerned about pharmaceutical pollution.
酮洛芬是一种常用于人类和兽医学的双环非甾体抗炎药，最近被认为是一种环境污染物，引发了对生态健康的担忧。由于其外消旋混合物、对映体和转化产物，它构成了日益严重的威胁，这些物质对包括无脊椎动物、脊椎动物、植物和微生物在内的各种生物具有生态毒理学影响。此外，酮洛芬在整个食物链中会发生生物累积和生物放大，威胁生态系统功能。令人惊讶的是，尽管存在这些担忧，但酮洛芬目前并未被视为优先物质。虽然有人提议对酮洛芬进行有针对性的生态药物警戒，但关于酮洛芬作为药物污染物的数据有限且不完整。本综述旨在全面总结最新研究结果（2017年至2023年3月），内容涉及酮洛芬在环境中的全球分布、对水生动物和植物的生态毒性以及现有的去除方法。特别强调了解酮洛芬如何影响在地球生态系统中起关键作用的微生物。该综述广泛涵盖了酮洛芬生物降解的各种方法，包括全细胞真菌和细菌系统以及酶生物催化剂。此外，还探讨了藻类吸附和植物修复去除酮洛芬的潜力。本综述将吸引广泛的读者，包括生态学家、微生物学家、政策制定者以及关注药物污染的人士。
