太极拳联合 tDCS 对 MCI 患者认知功能的影响：一项随机对照试验。
Effects of Tai Chi combined with tDCS on cognitive function in patients with MCI: a randomized controlled trial.
机构信息
National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
出版信息
Front Public Health. 2023 Aug 7;11:1199246. doi: 10.3389/fpubh.2023.1199246. eCollection 2023.
BACKGROUND
Mild cognitive impairment (MCI) is a critical stage of dementia. Previous reviews have suggested that physical exercise combined with non-invasive brain stimulation is more beneficial for improving cognitive function. However, no targeted studies have confirmed the effect of Tai Chi combined with transcranial direct current stimulation (tDCS) on the improvement of cognitive function in patients with MCI. Thus, this randomized trial was conducted to assess the effect of Tai Chi combined with tDCS on the cognitive performance of patients with MCI.
METHODS
From April 2018 to February 2020, a randomized, single-blind clinical trial was conducted, involving 180 participants with MCI who were divided into four intervention groups: Tai Chi combined with tDCS (TCT), Tai Chi combined with sham tDCS (TCS), walking combined with tDCS (WAT), and walking combined with sham tDCS (WAS). All participants were assessed at baseline and 12 weeks for global cognitive function, memory, attention, and executive function.
RESULTS
At baseline, there were no significant differences in age, gender, education duration, body mass index, or the Baker Depression Inventory among the four groups ( ≥ 0.05). After 12 weeks of intervention, the TCT group showed greater improvements in MOCA scores, memory quotient scores, and digit-symbol coding task reaction time compared to the TCS, WAS, and WAT groups ( < 0.05). The TCT group also had a shorter Stroop test color reaction time compared to the WAS and WAT groups ( < 0.05), a higher increase in Auditory Verbal Learning Test-immediate recall than the TCS and WAT groups ( < 0.05), a shorter visual reaction time than the TCS group ( < 0.05), and a shorter sustained attention time compared to the WAT group ( < 0.05).
CONCLUSION
Tai Chi combined with tDCS effectively improves global cognitive performance, memory, execution function, and attention in patients with MCI. These findings suggest the potential clinical use of Tai Chi combined with tDCS as a physical exercise combined with a non-invasive brain stimulation intervention to improve cognitive function in older adults with MCI.
CLINICAL TRIAL REGISTRATION
ChiCTR1800015629.
背景
轻度认知障碍（MCI）是痴呆的关键阶段。先前的综述表明，将体育锻炼与非侵入性脑刺激相结合，更有利于改善认知功能。然而，目前尚无针对性研究证实太极拳结合经颅直流电刺激（tDCS）对改善 MCI 患者认知功能的效果。因此，本随机试验旨在评估太极拳结合 tDCS 对 MCI 患者认知表现的影响。
方法
本研究于 2018 年 4 月至 2020 年 2 月进行了一项随机、单盲临床试验，纳入了 180 名 MCI 患者，将其分为四组干预组：太极拳结合 tDCS（TCT）、太极拳结合假 tDCS（TCS）、散步结合 tDCS（WAT）和散步结合假 tDCS（WAS）。所有参与者在基线和 12 周时评估整体认知功能、记忆、注意力和执行功能。
结果
在基线时，四组患者的年龄、性别、教育年限、体重指数或贝克抑郁量表无显著差异（≥0.05）。干预 12 周后，与 TCS、WAS 和 WAT 组相比，TCT 组 MOCA 评分、记忆商数评分和数字符号编码任务反应时间的改善更明显（<0.05）。与 WAS 和 WAT 组相比，TCT 组的 Stroop 测试颜色反应时间更短（<0.05），与 TCS 和 WAT 组相比，听觉词语学习测验即时回忆的增幅更高（<0.05），与 TCS 组相比，视觉反应时间更短（<0.05），与 WAT 组相比，持续注意力时间更短（<0.05）。
结论
太极拳结合 tDCS 可有效改善 MCI 患者的整体认知表现、记忆力、执行功能和注意力。这些发现表明，太极拳结合 tDCS 作为一种结合非侵入性脑刺激的体育锻炼，有可能用于改善老年 MCI 患者的认知功能。
临床试验注册
ChiCTR1800015629。
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