Ha Edward T, Taylor Kent D, Raffield Laura M, Briggs Matt, Yee Aaron, Elemento Olivier, Parikh Manish, Peterson Stephen J, Frishman William, Gerszten Robert E, Wilson James G, Kelsey Karl, Tahir Usman A, Reiner Alex, Auer Paul, Seeman Teresa, Rich Stephen S, Carson April P, Post Wendy S, Rotter Jerome I, Aronow Wilbert S
medRxiv. 2023 Aug 8:2023.08.03.23293626. doi: 10.1101/2023.08.03.23293626.
Black adults have higher incidence of all-cause death and worse cardiovascular outcomes when compared to other populations. The Duffy chemokine receptor is not expressed in a large majority of Black adults and the clinical implications of this are unclear.
Here, we investigated the relationship of Duffy receptor status, high-sensitivity C-reactive protein (hs-CRP), and long-term cardiovascular outcomes in Black members of two contemporary, longitudinal cohort studies (the Jackson Heart Study and Multi-Ethnic Study of Atherosclerosis). Data on 4,307 Black participants (2,942 Duffy null and 1,365 Duffy receptor positive, as defined using Single Nucleotide Polymorphism (SNP) rs2814778) were included in this analysis.
Duffy null was not independently associated with elevated levels of serum hs-CRP levels once conditioning for known locus alleles in linkage disequilibrium with the Duffy gene. Duffy null status was not found to be independently associated with higher incidence of all-cause mortality or secondary outcomes after adjusting for possible confounders in Black participants.
These findings suggest that increased levels of hs-CRP found in Duffy null individuals is due to co-inheritance of CRP alleles known to influence circulating levels hs-CRP and that Duffy null status was not associated with worse adverse outcomes over the follow-up period in this cohort of well-balanced Black participants.
与其他人群相比，成年黑人全因死亡发生率更高，心血管结局更差。大多数成年黑人不表达达菲趋化因子受体，其临床意义尚不清楚。
在此，我们在两项当代纵向队列研究（杰克逊心脏研究和动脉粥样硬化多族裔研究）的黑人成员中，研究了达菲受体状态、高敏C反应蛋白（hs-CRP）与长期心血管结局之间的关系。本分析纳入了4307名黑人参与者的数据（2942名达菲阴性和1365名达菲受体阳性，使用单核苷酸多态性（SNP）rs2814778定义）。
在对与达菲基因处于连锁不平衡的已知基因座等位基因进行校正后，达菲阴性与血清hs-CRP水平升高无独立相关性。在对黑人参与者的可能混杂因素进行校正后，未发现达菲阴性状态与全因死亡率或次要结局的更高发生率独立相关。
这些发现表明，达菲阴性个体中hs-CRP水平升高是由于已知影响循环hs-CRP水平的CRP等位基因的共同遗传，并且在这个平衡良好的黑人参与者队列中，达菲阴性状态与随访期间更差的不良结局无关。
