Sann L, Darre E, Lasne Y, Bourgeois J, Bethenod M
J Pediatr. 1986 Oct;109(4):681-6. doi: 10.1016/s0022-3476(86)80242-6.
Forty-two term and 106 preterm appropriate for gestational age (AGA), and 43 term and 31 preterm small for gestational age (SGA) children were observed from birth to age 5 years. Parents' weight and height were also measured in 193 subjects including 97 couples. The percentage of short children was higher in SGA (17%) than in AGA (3.4%) children (P less than 0.01). This difference was significant in the preterm but not in the term children, suggesting that early failure of growth in utero can result in reduced growth in children. The findings were similar for weight and head circumference, but microcephaly was more frequent in term SGA (30%) than in preterm SGA (6.4%) children (P less than 0.05), suggesting that late impaired growth in utero can result in poor growth of the head. Height at the age of 5 years correlated with the parents' height only in AGA children, and with length at birth in SGA children. Weight of the 5-year-old children correlated with the mother's weight only in AGA children. Multivariate analysis in 66 couples and their children confirmed a greater tendency toward the influence of parental factors in AGA children and a more significant relationship with perinatal factors in SGA children.
对42名足月儿和106名适于胎龄的早产儿，以及43名足月儿和31名小于胎龄的早产儿进行了从出生至5岁的观察。在包括97对夫妇在内的193名研究对象中还测量了父母的体重和身高。小于胎龄儿中身材矮小儿童的比例（17%）高于适于胎龄儿（3.4%）（P<0.01）。这种差异在早产儿中显著，但在足月儿中不显著，提示子宫内早期生长失败可导致儿童期生长减缓。体重和头围的研究结果相似，但足月小于胎龄儿小头畸形的发生率（30%）高于早产小于胎龄儿（6.4%）（P<0.05），提示子宫内后期生长受损可导致头部生长不良。5岁时的身高仅与适于胎龄儿的父母身高相关，而与小于胎龄儿的出生身长相关。5岁儿童的体重仅与适于胎龄儿的母亲体重相关。对66对夫妇及其子女的多因素分析证实，父母因素对适于胎龄儿的影响倾向更大，而小于胎龄儿与围产期因素的关系更显著。
