基因多态性对舒芬太尼分娩镇痛效果的影响：基于倾向评分匹配的队列研究。
Effect of gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching.
机构信息
Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, 361003, China.
School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361003, China.
出版信息
Pharmacogenomics. 2023 Aug;24(12):675-684. doi: 10.2217/pgs-2023-0103. Epub 2023 Aug 23.
This study investigated the use of G1947A and A118G polymorphisms as predictive markers for sufentanil epidural analgesia. The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis. AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 μg vs 17.11 μg; p = 0.049) than AA carriers. GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021). Sufentanil may provide better epidural labor analgesia in AA and GA/AA carriers compared with AG/GG and GG carriers. : ChiCTR1900026897 (Chinese Clinical Trial Center Registry).
本研究探讨了 G1947A 和 A118G 多态性作为预测舒芬太尼硬膜外镇痛的标记物。使用视觉模拟评分（VAS）评分和 136 对使用舒芬太尼与利多卡因和罗哌卡因行硬膜外镇痛的产妇的舒芬太尼消耗量进行分析。AG/GG 组产妇在第五分钟和 0 分钟之间的 VAS 评分差值较低（1.55 比 1.87;p=0.012），舒芬太尼消耗量较高（19.65μg 比 17.11μg;p=0.049）。GA/AA 组产妇的 VAS 评分差值高于 GG 组（1.86 比 1.55;p=0.021）。与 AG/GG 和 GG 组相比，AA 和 GA/AA 组产妇舒芬太尼可能提供更好的硬膜外分娩镇痛。ChiCTR1900026897（中国临床试验注册中心）。
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