This study investigated the use of G1947A and A118G polymorphisms as predictive markers for sufentanil epidural analgesia. The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis. AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 μg vs 17.11 μg; p = 0.049) than AA carriers. GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021). Sufentanil may provide better epidural labor analgesia in AA and GA/AA carriers compared with AG/GG and GG carriers. : ChiCTR1900026897 (Chinese Clinical Trial Center Registry).