Sarmanlu Mesud, Kuypers Kim P C, Vizeli Patrick, Kvamme Timo L
Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Prog Neuropsychopharmacol Biol Psychiatry. 2024 Jan 10;128:110843. doi: 10.1016/j.pnpbp.2023.110843. Epub 2023 Aug 21.
The application of MDMA in conjunction with psychotherapy has in recent years seen a resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress disorder (PTSD). Clinical trials have shown promising safety and efficacy, but the mechanisms underlying this treatment form remain largely unestablished. This article explores recent preclinical and clinical evidence suggesting that the treatment's efficacy may be influenced by the mnemonic effects of MDMA. We review data on the effects of MDMA on fear extinction and fear reconsolidation and the utility of these processes for PTSD treatment. We corroborate our findings by incorporating research from cognitive psychology and psychopharmacology and offer recommendations for future research.
近年来，3,4－亚甲基二氧甲基苯丙胺（MDMA）与心理治疗相结合的方法在治疗创伤后应激障碍（PTSD）方面重新引起了临床、科学和公众的关注。临床试验显示出了良好的安全性和有效性，但这种治疗形式的潜在机制在很大程度上仍未明确。本文探讨了近期的临床前和临床证据，这些证据表明该治疗的疗效可能受MDMA记忆效应的影响。我们回顾了关于MDMA对恐惧消退和恐惧重新巩固的影响的数据，以及这些过程在PTSD治疗中的效用。我们通过纳入认知心理学和精神药理学的研究来证实我们的发现，并为未来的研究提供建议。
