Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Curr Pharm Des. 2023;29(43):3497-3503. doi: 10.2174/1381612829666230823091226.
Inflammation is a well-described factor in the pathophysiology of type 2 diabetes mellitus (DM), which has been a suspect in the alteration of correlations between CRP and leptin in patients with type 2 DM.
This study aimed to show the effect of vitamin C as an antioxidant on the correlation of the serum levels of C-reactive protein (CRP) and leptin in patients with type 2 DM.
We recruited 70 patients with longstanding T2DM and randomly assigned them into two groups; one received 500 mg/day of vitamin C, and the other received a placebo for eight weeks. Both groups were matched regarding baseline characteristics such as age, gender, weight, and diabetic medications.
Out of 70 individuals, 57 participants were left in the study. After eight weeks of follow-up, leptin level was significantly increased in the Vitamin C group (MD = 3.48 change = 24%, p-value = 0.001) but did not change in the placebo group. Other markers such as Fasting plasma glucose, HbA1c, Creatinine, uric acid, Urea, cholesterol, HDL, LDL, TG, AST, ALT, insulin, and CRP did not significantly change in both groups (p value > 0.05). The significant changes in the leptin level among the vitamin C group also remained after controlling for age, BMI, Blood pressure (BP), Triglyceride (TG), and cholesterol. Also, the correlation between serum CRP and leptin became significant in the vitamin C group after eight weeks of follow-up but not in the placebo group. (rs = 0.730, p < 0.001 vs. rs = 0.286, p-value = 0.266 in placebo group).
This study shows vitamin C can restore CRP-leptin correlation in patients with type 2 diabetes and increase serum leptin levels. More studies are needed to clarify the mechanism of this restoration.
IRCT20160811029306N1.
炎症是 2 型糖尿病（DM）病理生理学中描述明确的一个因素，这一因素一直被怀疑会改变 2 型 DM 患者 CRP 和瘦素之间的相关性。
本研究旨在表明维生素 C 作为一种抗氧化剂对 2 型糖尿病患者血清 C 反应蛋白（CRP）和瘦素相关性的影响。
我们招募了 70 名患有长期 2 型糖尿病的患者，并将他们随机分为两组；一组每天服用 500 毫克维生素 C，另一组服用安慰剂 8 周。两组在年龄、性别、体重和糖尿病药物等基线特征方面相匹配。
在 70 名个体中，有 57 名参与者留在研究中。经过 8 周的随访，维生素 C 组的瘦素水平显著升高（MD=3.48 变化=24%，p 值=0.001），而安慰剂组则没有变化。其他标志物，如空腹血糖、HbA1c、肌酐、尿酸、尿素、胆固醇、HDL、LDL、TG、AST、ALT、胰岛素和 CRP，在两组中均无显著变化（p 值>0.05）。在控制年龄、BMI、血压（BP）、甘油三酯（TG）和胆固醇后，维生素 C 组瘦素水平的显著变化仍然存在。此外，在 8 周的随访后，维生素 C 组血清 CRP 与瘦素之间的相关性变得显著，但安慰剂组则没有。（rs=0.730，p<0.001 与 rs=0.286，安慰剂组 p 值=0.266）。
本研究表明，维生素 C 可以恢复 2 型糖尿病患者 CRP-瘦素的相关性，并增加血清瘦素水平。需要进一步的研究来阐明这种恢复的机制。
IRCT20160811029306N1。
