Sinha Abhishek, Gupta Sweta, Taruna Taruna, Priya Leena, Jha Awanindra K, Golwara Amesh, Gore Navmi R
Department of Dentistry, Patna Medical College and Hospital, Patna, IND.
Departmental of Orthodontics and Dentofacial Orthopedics, Patna Dental College and Hospital, Patna, IND.
Cureus. 2023 Jul 22;15(7):e42309. doi: 10.7759/cureus.42309. eCollection 2023 Jul.
Previous literature data has extensively assessed the biocompatibility of various orthodontic adhesives and their components, where the results of most of the studies showed cytotoxic effects of different degrees owing to the unbound molecules released structurally from the cured components.
The present in-vitro study was aimed to assess the release of titanium dioxide nanoparticles in the artificial saliva from the orthodontic composites impregnated with titanium dioxide nanoparticles of 5% w/w (weight/weight) and 1% w/w used for metal brackets bonding.
The study assessed 160 teeth extracted freshly during orthodontic treatment and divided into two groups of 80 samples, each that bonded to orthodontic brackets having 5% w/w and 1% w/w composites with titanium dioxide nanoparticles kept in the artificial saliva. Quantification was done for 5% w/w and 1% w/w composites having titanium nanoparticles with inductively coupled plasma mass spectroscopy at 24 hours, two, four, and six months.
It was seen that in teeth with 1% titanium dioxide, the greatest titanium release was seen at two months, with non-significant release after two months. In teeth with 5% w/w titanium dioxide nanoparticles showed significant titanium release all the time. A significantly greater titanium dioxide release on increasing concentration from 1% to 5% was seen for the 5% w/w group at all the assessment times.
The present study concludes that a higher release of titanium is seen in 5% w/w composite containing titanium dioxide nanoparticles, and the concentrations of 1% and 5% can be safely used and are considered to be within permissible limits.
以往的文献数据广泛评估了各种正畸粘合剂及其成分的生物相容性，大多数研究结果表明，由于固化成分结构释放出未结合的分子，不同程度地存在细胞毒性作用。
本体外研究旨在评估含5%重量/重量（w/w）和1% w/w二氧化钛纳米颗粒的正畸复合材料在人工唾液中二氧化钛纳米颗粒的释放情况，这些复合材料用于金属托槽粘结。
该研究评估了正畸治疗期间新鲜拔除的160颗牙齿，分为两组，每组80个样本，每个样本粘结到含5% w/w和1% w/w二氧化钛纳米颗粒复合材料的正畸托槽上，并置于人工唾液中。采用电感耦合等离子体质谱法对含钛纳米颗粒的5% w/w和1% w/w复合材料在24小时、2个月、4个月和6个月时进行定量分析。
结果显示，在含1%二氧化钛的牙齿中，两个月时钛释放量最大，两个月后释放量无显著变化。在含5% w/w二氧化钛纳米颗粒的牙齿中，钛一直有显著释放。在所有评估时间点，5% w/w组从1%增加到5%浓度时，二氧化钛释放量显著增加。
本研究得出结论，含二氧化钛纳米颗粒的5% w/w复合材料中钛释放量更高，1%和5%的浓度可安全使用，且被认为在允许范围内。
