Saha Shubham, Singh Praveen, Dutta Abhi, Vaidya Hiteshi, Negi Prakash Chand, Sengupta Shantanu, Seth Sandeep, Basak Trayambak
School of Biosciences and Bioengineering. IIT-Mandi, Mandi, India.
BioX Center, Indian Institute of Technology-Mandi, Mandi, India.
JACC Asia. 2023 Jul 18;3(4):539-555. doi: 10.1016/j.jacasi.2023.06.001. eCollection 2023 Aug.
Dilated cardiomyopathy (DCM) is one of the major causes of heart failure characterized by the enlargement of the left ventricular cavity and contractile dysfunction of the myocardium. Lipids are the major sources of energy for the myocardium. Impairment of lipid homeostasis has a potential role in the pathogenesis of DCM. In this review, we have summarized the role of different lipids in the progression of DCM that can be considered as potential biomarkers. Further, we have also explained the mechanistic pathways followed by the lipid molecules in disease progression along with the cardioprotective role of certain lipids. As the global epidemiological status of DCM is alarming, it is high time to define some disease-specific biomarkers with greater prognostic value. We are proposing an adaptation of a system lipidomics-based approach to profile DCM patients in order to achieve a better diagnosis and prognosis of the disease.
扩张型心肌病（DCM）是心力衰竭的主要原因之一，其特征为左心室腔扩大和心肌收缩功能障碍。脂质是心肌的主要能量来源。脂质稳态受损在DCM的发病机制中具有潜在作用。在本综述中，我们总结了不同脂质在DCM进展中的作用，这些脂质可被视为潜在的生物标志物。此外，我们还解释了脂质分子在疾病进展中遵循的机制途径以及某些脂质的心脏保护作用。由于DCM的全球流行病学状况令人担忧，现在是时候定义一些具有更高预后价值的疾病特异性生物标志物了。我们建议采用基于系统脂质组学的方法来分析DCM患者，以实现对该疾病更好的诊断和预后评估。
